ReviewAnalytical and bioanalytical chemistry2017
Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing.
Review in Analytical and bioanalytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of raman spectroscopy in the diagnosis of kidney cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Raman-guided sample subset selection for cost-efficient offline calibration in bioprocesses.Bioprocess and biosystems engineering · 2026Article
- Development and Integrated Application of the Multi-Attribute Method (MAM) in Quality Control of Biotechnological Drugs.Biotechnology and bioengineering · 2026Review
- Limits and benefits of unsupervised transfer learning for Raman spectroscopy-based bioprocess monitoring.Bioprocess and biosystems engineering · 2026Article
- High-Throughput eSWIR Hyperspectral Imaging for Pharmaceutical Classification at Industrial Line Speeds.AAPS PharmSciTech · 2026Article
- Variable-specific preprocessing enables cross-scale transferable Raman models from high-throughput bioreactor data.Bioresources and bioprocessing · 2026Article
- Quality by Design and Process Analytical Technology for On-Demand Drug Manufacturing Through 3D Printing.Pharmaceutics · 2026Review
- Online Raman spectroscopy-guided strategy for efficient production of DNA recombinase UvsX in Escherichia coli.Analytical and bioanalytical chemistry · 2026Article
- Next-Generation Bionic Sensors for Small Molecule Detection: Integrating Synthetic Biology, Nanomaterials, and Artificial Intelligence.Micromachines · 2026Review
- Impurity Characterization Across Drug Development Stages: Analytical Methodologies and Regulatory Perspectives.Pharmaceutical research · 2026Review
- Ecology-microbiome engineering in Sauce-flavor Baijiu via Single-Cell Raman Spectroscopy.Biodesign research · 2026Review
- Spectroscopy-Based Cell Culture Predictive Monitoring.Biotech (Basel (Switzerland)) · 2026Article
- Evaluation of cadmium's impact on marine mussels: insights from Raman spectroscopy and chemometric analysis.Analytical and bioanalytical chemistry · 2026Article
- Application of vibrational spectroscopies as process analytical techniques for monitoring fermentation and the conversion of lignocellulosic biomass by oleaginous filamentous fungi.Microbial cell factories · 2025Article
- Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media.Nano letters · 2025Article
- Article
- Open-source Raman spectra of chemical compounds for active pharmaceutical ingredient development.Scientific data · 2025Article
- Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media.bioRxiv : the preprint server for biology · 2025Article
- To Acquire or Not to Acquire: Evaluating Compressive Sensing for Raman Spectroscopy in Biology.ACS sensors · 2025Article
- Completely noninvasive multi-analyte monitoring system for cell culture processes.Biotechnology letters · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Adoption of Quality by Design (QbD) principles, regulatory support of QbD, process analytical technology (PAT), and continuous manufacturing are major factors effecting new approaches to pharmaceutical manufacturing and bioprocessing. In this review, we highlight new technology developments, data analysis models, and applications of Raman spectroscopy, which have expanded the scope of Raman spectroscopy as a process analytical technology. Emerging technologies such as transmission and enhanced reflection Raman, and new approaches to using available technologies, expand the scope of Raman spectroscopy in pharmaceutical manufacturing, and now Raman spectroscopy is successfully integrated into real-time release testing, continuous manufacturing, and statistical process control. Since the last major review of Raman as a pharmaceutical PAT in 2010, many new Raman applications in bioprocessing have emerged. Exciting reports of in situ Raman spectroscopy in bioprocesses complement a growing scientific field of biological and biomedical Raman spectroscopy. Raman spectroscopy has made a positive impact as a process analytical and control tool for pharmaceutical manufacturing and bioprocessing, with demonstrated scientific and financial benefits throughout a product's lifecycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.