ArticleThe Journal of clinical endocrinology and metabolism2016
Use of Estrogen-Containing Contraception Is Associated With Increased Concentrations of 25-Hydroxy Vitamin D.
Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 56 citations in OpenAlex.
- Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial.Nutrients · 2017Trial
- Dairy Intake and Uterine Fibroid Development: A Prospective Study.Journal of women's health (2002) · 2026Article
- The Use of Combined Oral Contraceptives for ˃6 Months Is Not Associated with Body Fat or Bone Density, Regardless of Dietary Differences-A Pilot Study.Medicina (Kaunas, Lithuania) · 2026Article
- Preparation of a Supramolecular Assembly of Vitamin D in a β-Cyclodextrin Shell with Silver Nanoparticles.Molecules (Basel, Switzerland) · 2025Article
- The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review.Annals of medicine · 2025Review
- Estrogen-containing contraceptive use and blood lead concentrations in a cohort of premenopausal individuals.Environmental research · 2025Article
- Vitamin D Deficiency and Supplementation in Irritable Bowel Syndrome: Retrospective Evaluation of Subtype and Sex-Based Differences.Medicina (Kaunas, Lithuania) · 2025Article
- Hormonal and metabolic responses across phases of combined oral contraceptive use and menstrual cycle in young elite female athletes.European journal of applied physiology · 2025Article
- The Quantification of Vitamin D in Humans: A Promising, Non-Invasive and Cost-Effective Method to Measure 25-Hydroxyvitamin D.Biomolecules · 2025Article
- A comparative study of hormonal contraceptive use and vitamin D levels at Gondar Town 2023.Scientific reports · 2024Article
- Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women.Fertility and sterility · 2024Article
- Vitamin D Status During Adolescence and the Impact of Lifestyle Changes: 2 Years' Follow-up From the Fit Futures Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Combined oral contraceptive utilization and uterine fibroid incidence: A prospective study in a cohort of African-American women.PloS one · 2024Article
- Hypovitaminosis D in university workers in Southern Ecuador: interactions between gender and lifestyle.Frontiers in nutrition · 2024Article
- Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach).International journal of molecular sciences · 2023Review
- Serum vitamin D in sanctuary chimpanzees (Pan troglodytes) in range countries: A pilot study.Veterinary medicine and science · 2023Article
- Clarifying the Heterogeneity in Response to Vitamin D in the Development, Prevention, and Treatment of Type 2 Diabetes Mellitus: A Narrative Review.International journal of environmental research and public health · 2023Review
- A Cross-Sectional Study of the Associations between Biomarkers of Vitamin D, Iron Status, and Hemoglobin in South African Women of Reproductive Age: the Healthy Life Trajectories Initiative, South Africa.Current developments in nutrition · 2023Article
- Vitamin DLife (Basel, Switzerland) · 2023Article
- Decreased Vitamin D Levels and Altered Placental Vitamin D Gene Expression at High Altitude: Role of Genetic Ancestry.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
contextSmall studies suggest exogenous estrogen may improve vitamin D status, but the etiology is unclear because women who use hormones may make lifestyle choices that differentially affect vitamin D status.
objectiveOur objective was to investigate the association between use of hormonal contraception and 25-hydroxy-vitamin D (25(OH)D).
designWe used linear regression modeling of cross-sectional data to estimate percent change in season-adjusted serum 25(OH)D with estrogen use after adjustment for other factors.
settingAt the enrollment clinic visit (2010-2012) into a cohort study of uterine fibroids, each subject provided a blood sample, had anthropomorphic variables and skin reflectance measured, and answered questionnaires on demographics, dietary and supplement intake, contraceptive use, reproductive and medical history, and behaviors.
participantsA total of 1662 African American women, community volunteers, 23-34 years old, living in the Detroit, Michigan, area were included.
interventionsNone. MAIN OUTCOMES AND MEASURES: Serum 25(OH)D was measured.
resultsSerum 25(OH)D concentrations were low (70% <20 ng/ml). Current use of an estrogen-containing contraceptive was associated with a 20% (95% confidence interval: 14-27) increase in 25(OH)D after adjustment. There was no increase in 25(OH)D among participants who had used estrogen in the past, but were not current users, indicating that results were unlikely to be due to unmeasured confounding by factors related to contraceptive choice.
conclusionsThe increase in 25(OH)D with use of estrogen-containing contraceptives raise mechanistic questions regarding the biological pathways involved, and highlights the need for studies that examine possible endogenous estrogen effects on vitamin D.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.