ArticleBritish journal of cancer2016
Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case-control study.
Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies.Breast cancer research : BCR · 2019Pooled it
- Advance and challenge of DNA methylation as cancer biomarkers for risk stratification, screening and early detection.Journal of the National Cancer Center · 2025Article
- A prospective study of smoking-related white blood cell DNA methylation markers and risk of bladder cancer.European journal of epidemiology · 2024Article
- Relationship between Bladder Cancer, Nutritional Supply, and Treatment Strategies: A Comprehensive Review.Nutrients · 2023Review
- Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?Epigenetics · 2022Article
- Repeatability of methylation measures using a QIAseq targeted methyl panel and comparison with the Illumina HumanMethylation450 assay.BMC research notes · 2021Article
- Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study.JNCI cancer spectrum · 2021Article
- A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility.BMC cancer · 2020Article
- Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility.Epigenetics · 2020Article
- One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition.International journal of cancer · 2019Article
- DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors.Scientific reports · 2019Article
- Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults.Biomarker research · 2019Article
- Article
- Genome-wide average DNA methylation is determined in utero.International journal of epidemiology · 2018Article
- Epigenetic supersimilarity of monozygotic twin pairs.Genome biology · 2018Article
- Twin birth changes DNA methylation of subsequent siblings.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlobal DNA methylation has been reported to be associated with urothelial cell carcinoma (UCC) by studies using blood samples collected at diagnosis. Using the Illumina HumanMethylation450 assay, we derived genome-wide measures of blood DNA methylation and assessed them for their prospective association with UCC risk.
methodsWe used 439 case-control pairs from the Melbourne Collaborative Cohort Study matched on age, sex, country of birth, DNA sample type, and collection period. Conditional logistic regression was used to compute odds ratios (OR) of UCC risk per s.d. of each genome-wide measure of DNA methylation and 95% confidence intervals (CIs), adjusted for potential confounders. We also investigated associations by disease subtype, sex, smoking, and time since blood collection.
resultsThe risk of superficial UCC was decreased for individuals with higher levels of our genome-wide DNA methylation measure (OR=0.71, 95% CI: 0.54-0.94; P=0.02). This association was particularly strong for current smokers at sample collection (OR=0.47, 95% CI: 0.27-0.83). Intermediate levels of our genome-wide measure were associated with decreased risk of invasive UCC. Some variation was observed between UCC subtypes and the location and regulatory function of the CpGs included in the genome-wide measures of methylation.
conclusionsHigher levels of our genome-wide DNA methylation measure were associated with decreased risk of superficial UCC and intermediate levels were associated with reduced risk of invasive disease. These findings require replication by other prospective studies.
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