ArticleClinical & experimental ophthalmology2017
Effect of mitomycin c and 5-flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation.
Article in Clinical & experimental ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06680245 (Effect of Mitomycin-C on the Outcomes of Patients Receiving Ahmed Glaucoma Valve Implantation Surgery), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Mitomycin-C on the Outcomes of Patients Receiving Ahmed Glaucoma Valve Implantation Surgery
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Ahmed glaucoma valve implantation with and without subconjunctival bevacizumab in refractory glaucoma.International ophthalmology · 2021Trial
- Comparison between Ahmed glaucoma valve implant and Keiki Mehta body pressure glaucoma implant in neovascular glaucoma: 24-month results.International journal of ophthalmology · 2026Article
- Surgical outcomes of Ahmed Glaucoma Valve Implantation surgery: With mitomycin C and without mitomycin C.Journal of the colleges of medicine of South Africa · 2026Article
- Paul versus Baerveldt 350 glaucoma drainage implants: One-year comparative analysis.Indian journal of ophthalmology · 2025Article
- Effect of Intraoperative Mitomycin C on the Surgical Outcomes of Ahmed Glaucoma Valve Implantation with Ciliary Sulcus Tube Placement.Korean journal of ophthalmology : KJO · 2023Article
- Factors associated with vision loss in Black or Hispanic patients 1 year after standalone or combined Ahmed glaucoma valve surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Comparison of Surgical Outcomes between Trabeculectomy with Mitomycin C and Ahmed Valve Implantation with Mitomycin C in Eyes with Uveitic Glaucoma.Journal of clinical medicine · 2022Article
- Factors associated with the surgical outcomes of Baerveldt glaucoma implant for open-angle glaucoma, an age-related eye disease.Scientific reports · 2022Article
- Modified Trabeculectomy versus Glaucoma Drainage Implant Surgery: A Retrospective Comparative Study for Refractory Glaucoma Treatment.Oxidative medicine and cellular longevity · 2022Article
- Pars plana vitrectomy combined with pan-retinal photocoagulation, Ahmed glaucoma valve implantation, and/or phacoemulsification for complicated neovascular glaucoma treatment.Arquivos brasileiros de oftalmologia · 2022Article
- The Effect of Tube Location on Corneal Endothelial Cells in Patients with Ahmed Glaucoma Valve.Ophthalmology · 2021Article
- Outcomes of Ahmed glaucoma valve FP8 versus FP7 in adult secondary glaucoma.International ophthalmology · 2020Article
- Use of Anti-VEGF Agents in Glaucoma Surgery.Journal of ophthalmology · 2017Review
- Short-term Postoperative Visual Acuity Decrease and Recovery after Ahmed Tube Shunt Procedure for Glaucoma.Ophthalmology. GlaucomaArticle
- Improving Glaucoma Surgical Outcomes with Adjunct Tools.Journal of current glaucoma practiceReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTo examine the effect of mitomycin c and 5-flurouracil on treatment outcomes following Ahmed glaucoma valve implantation.
designRetrospective consecutive case series.
participantsFifty patients who received Ahmed glaucoma valve implantation from 1999 to 2013 in the San Francisco Veterans Administration Hospital.
methodsThe +INJECTION group received intraoperative mitomycin c followed by postoperative mitomycin c and/or 5-flurouracil, whereas the -INJECTION group did not.
main outcome measuresPrimary outcome was treatment success at 1 year post-implantation. Intraocular pressure, hypertensive phase, and the number of glaucoma medications were also examined.
resultsTwenty-six patients/eyes in the +INJECTION group and 24 patients/eyes in the -INJECTION group were included. Treatment success was higher in the +INJECTION compared with the -INJECTION group (86 vs. 58%; P = 0.04). Intraocular pressure was lower in the +INJECTION compared with the -INJECTION group at 1, 3, 6 and 12 months (P ≪ 0.00001, P = 0.00003, 0.0008 and 0.024). Hypertensive phase occurred less often in the +INJECTION compared with the -INJECTION group (3.8 vs. 54%; P = 0.021). The +INJECTION group required fewer medications compared with the -INJECTION group (P = 0.02, 0.002, 0.003 and 0.008 at 1, 3, 6 and 12 months). Complication rates were comparable between groups (46.2 and 54.2%; P = 0.63).
conclusionsAdjuvant treatment with antifibrotics following Ahmed glaucoma valve implantation decreased the hypertensive phase and improved surgical outcomes without impacting complication rates at 1 year. This study postulates a role for antifibrotics in the postoperative management of Ahmed glaucoma valves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.