ArticlePediatric research2016
Inotropes do not increase cardiac output or cerebral blood flow in preterm piglets.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Impact of prematurity on lifelong cardiovascular health: structural and functional considerations.NPJ cardiovascular health · 2024Review
- Red cell infusion but not saline is effective for volume expansion in preterm piglets.Pediatric research · 2023Article
- Preterm pigs for preterm birth research: reasonably feasible.Frontiers in physiology · 2023Review
- Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment.Journal of clinical medicine · 2021Review
- Blood Pressure Profiles in Infants With Hypoxic Ischemic Encephalopathy (HIE), Response to Dopamine, and Association With Brain Injury.Frontiers in pediatrics · 2020Article
- Reduced blood volume decreases cerebral blood flow in preterm piglets.The Journal of physiology · 2018Article
- Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia.Pediatric research · 2018Article
- Cardiovascular Supportive Therapies for Neonates With Asphyxia - A Literature Review of Pre-clinical and Clinical Studies.Frontiers in pediatrics · 2018Review
- Treating Hypotension in Preterm Neonates With Vasoactive Medications.Frontiers in pediatrics · 2018Review
- Inotropes for Preterm Infants: 50 Years on Are We Any Wiser?Frontiers in pediatrics · 2018Review
- Structure, organization and tissue expression of the pigBiochemistry and biophysics reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe preterm newborn is at high risk of developing cardiovascular compromise during the first day of life and this is associated with increased risk of brain injury. Standard treatments are volume expansion and administration of inotropes, typically dopamine and/or dobutamine, but there is limited evidence that inotropes improve clinical outcomes. This study investigated the efficacy of dopamine and dobutamine for the treatment of cardiovascular compromise in the preterm newborn using a piglet model.
methodsPreterm and term piglets were assigned to either dopamine, dobutamine or control infusions. Heart rate, left ventricular contractility, cardiac output, blood pressure, and cerebral and regional blood flows were measured during baseline, low (10 µg/kg/h), and high (20 µg/kg/h) dose infusions.
resultsAt baseline, preterm piglets had lower cardiac contractility, cardiac output, blood pressure, and cerebral blood flow compared to term piglets. The response of preterm piglets to either dopamine or dobutamine administration was less than in term piglets. In both preterm and term piglets, cardiac output and cerebral blood flow were unaltered by either inotrope.
conclusionIn order to provide better cardiovascular support, it may be necessary to develop treatments that target receptors with a more mature profile than adrenoceptors in the preterm newborn.
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