ArticleAIDS (London, England)2016
Advancing HIV research with pregnant women: navigating challenges and opportunities.
Article in AIDS (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Systematic review of research focused on pregnant and postpartum women living with HIV: A relational ethics perspective.Bioethics · 2021Pooled it
- Ethical considerations for research involving pregnant women living with HIV and their young children: a systematic review of the empiric literature and discussion.BMC medical ethics · 2021Pooled it
- Advancing the inclusion of pregnant and lactating populations in HIV PrEP research: ethical, regulatory, and surveillance recommendations from a multisectoral working group.Frontiers in public health · 2026Article
- Ethical considerations for research involving pregnant women with HIV and their children.AIDS (London, England) · 2025Article
- Beyond Viral Suppression: Navigating Structural Barriers, Aging and Frailty, Drug Resistance, Therapeutic Innovations, and Reproductive Health Challenges in the Global HIV/AIDS Epidemic.Journal of AIDS and HIV treatment · 2025Article
- "If it benefits someone, it will be good:" perspectives on research participation from pregnant women living with HIV.AIDS care · 2023Article
- Does Venue of HIV Testing and Results Disclosure in the Context of a Research Study Affect Adolescent Health and Behavior? Results from a Study in Western Kenya.International journal of environmental research and public health · 2022Article
- Ending the evidence gap for pregnancy, HIV and co-infections: ethics guidance from the PHASES project.Journal of the International AIDS Society · 2021Article
- Pregnant women & vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response.Vaccine · 2021Review
- Views among Malawian women about joining HIV prevention clinical trials when pregnant.AIDS research and therapy · 2020Article
- Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana.The New England journal of medicine · 2019Article
- Risk to Nonparticipants in HIV Remission Studies With Treatment Interruption: A Symposium.The Journal of infectious diseases · 2019Article
- Lessons from PrEP: A Qualitative Study Investigating How Clinical and Policy Experts Weigh Ethics and Evidence When Evaluating Preventive Medications for Use in Pregnant and Breastfeeding Women.AIDS and behavior · 2019Article
- Beyond "Vessels and Vectors": A Global Review of Registered HIV-Related Clinical Trials with Pregnant Women.Journal of women's health (2002) · 2019Review
- Women's Views About a Paternal Consent Requirement for Biomedical Research in Pregnancy.Journal of empirical research on human research ethics : JERHRE · 2018Article
- A Community Perspective on the Inclusion of Pregnant Women in Tuberculosis Drug Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Research with Pregnant Women: New Insights on Legal Decision-Making.The Hastings Center report · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveConcerns about including pregnant women in research have led to a dearth of evidence to guide safe and effective treatment and prevention of HIV in pregnancy. To better understand why these evidence gaps persist and inform guidance for responsible inclusion of pregnant women in the HIV research agenda, we aimed to learn what HIV experts perceive as barriers and constraints to conducting this research.
methodsWe conducted a series of group and one-on-one consultations with 62 HIV investigators and clinicians to elicit their views and experiences conducting HIV research involving pregnant women. Thematic analysis was used to identify priorities and perceived barriers to HIV research with pregnant women.
resultsExperts discussed a breadth of needed research, including safety, efficacy, and appropriate dosing of: newer antiretrovirals for pregnant women, emerging preventive strategies, and treatment for coinfections. Challenges to conducting research on pregnancy and HIV included ethical concerns, such as how to weigh risks and benefits in pregnancy; legal concerns, such as restrictive interpretations of current regulations and liability issues; financial and professional disincentives, including misaligned funder priorities and fear of reputational damage; and analytical and logistical complexities, such as challenges recruiting and retaining pregnant women to sufficiently power analyses.
conclusionInvestigators face numerous challenges to conducting needed HIV research with pregnant women. Advancing such research will require clearer guidance regarding ethical and legal uncertainties; incentives that encourage rather than discourage investigators to undertake such research; and a commitment to earlier development of safety and efficacy data through creative trial designs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.