Evidence map›Paper›PMID 27490609›Full record

ReviewPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2016

Sepsis in Pediatric Cardiac Intensive Care.

Derek S Wheeler, Hector R Wong

Abstract readReview
In one paragraph

Review in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. External Validation of the Phoenix Sepsis Score in a Single Pediatric Cardiac ICU.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Differences in the Genomic Profiles of Immunoparalyzed and Nonimmunoparalyzed Children With Sepsis: A Pilot Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022
    Observational
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Derek S WheelerBoth authors: Department of Pediatrics, Section of Critical Care Medicine, Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Hector R Wong
Cincinnati Children's Hospital Medical Center · US

Funding

Novel diagnostic and stratification tools for septic shockR01GM108025 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2014 to 2017
$2.3M
Stratification of pediatric septic shockR01GM099773 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2012 to 2015
$1.5M
MMP-8 as a novel therapeutic target in sepsisR01GM096994 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WONG, HECTOR R. · 2011 to 2014
$1.2M
Acceleration to Expertise: Simulation as a Tool to Improve the Recognition of SepR18HS020455 · AHRQ · CINCINNATI CHILDRENS HOSP MED CTR · PI GEIS, GARY LEE · 2011 to 2013
$1.0M
AHRQ HHS R18 HS020455NIGMS NIH HHS R01 GM096994NIGMS NIH HHS R01 GM099773NIGMS NIH HHS R01 GM108025
6 · The paper itself

Abstract

objectivesIn this review, we will discuss risk factors for developing sepsis; the role of biomarkers in establishing an early diagnosis, in monitoring therapeutic efficacy, in stratification, and for the identification of sepsis endotypes; and the pathophysiology and management of severe sepsis and septic shock, with an emphasis on the impact of sepsis on cardiovascular function. DATA SOURCE: MEDLINE and PubMed.

conclusionsThere is a lot of excitement in the field of sepsis research today. Scientific advances in the diagnosis and clinical staging of sepsis, as well as a personalized approach to the treatment of sepsis, offer tremendous promise for the future. However, at the same time, it is also evident that sepsis mortality has not improved enough, even with progress in our understanding of the molecular pathophysiology of sepsis.

Indexed as

BiomarkersChildCoronary Care UnitsHumansPediatricsRisk FactorsSepsisBiomarkers

Identifiers

PMID27490609
PMCPMC4975434
OpenAlexW2529127932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.