ArticleMolecules (Basel, Switzerland)2016
In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Randomized controlled clinical trial on the efficacy of a novel antimicrobial chewing gum in reducing plaque and gingivitis in adolescent orthodontic patients.Clinical oral investigations · 2024Trial
- In vitro assessment of experimental bioactive tooth gel formulas containing L-arginine, ginger and eggshell for remineralization and anti-bacterial effect.Scientific reports · 2026Article
- Retrospective Descriptive Case Series on the Use of AMCOPBioengineering (Basel, Switzerland) · 2026Article
- Natural Compounds in Oral Microbiota Modulation and Caries Prevention: A Systematic Review.Dentistry journal · 2025Review
- Saliva as a matrix for therapeutic drug monitoring and disease biomarkers in children and adolescents.Pharmacological reports : PR · 2025Review
- Experimental Study of Two-Bite Test Parameters for Effective Drug Release from Chewing Gum Using a Novel Bio-Engineered Testbed.Biomedicines · 2025Article
- In Vivo Study on the Salivary Kinetics of Two Probiotic Strains Delivered via Chewing Gum.Microorganisms · 2025Article
- The Role of Curcumin in Oral Health and Diseases: A Systematic Review.Antioxidants (Basel, Switzerland) · 2024Review
- Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention.Current issues in molecular biology · 2024Review
- Marine Bioactive Compounds as Nutraceutical and Functional Food Ingredients for Potential Oral Health.Frontiers in nutrition · 2021Review
- Comparison of Phenols Content and Antioxidant Activity of Fruits from Different Maturity Stages ofMolecules (Basel, Switzerland) · 2018Article
- New Frontiers on the Metabolism, Bioavailability and Health Effects of Phenolic Compounds.Molecules (Basel, Switzerland) · 2017Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in vivo trial; finally, to test their in vivo antibacterial effect against oral Streptococcus mutans strains. A preliminary study was performed to produce new gums, enriched with the polyphenol quercetin. Then, a first in vivo experimental study was assessed to test the percentages of Qt released in the saliva of young volunteers. Moreover, a second clinical trial was performed to analyze the antibacterial capability of these enriched chewing gums against S. mutans strains after 14 days of daily consumption. The release analysis showed that a more effective release of Qt occurs in the first minutes of chewing, and it does not change saliva pH values. Moreover, Qt included in gums demonstrates an effective antibacterial activity, showing a reduction of the concentration of S. mutans strains in saliva samples, especially after 7 days. Qt included in experimental chewing gums could be efficiently released into the oral cavity and could promote an effective anti-caries concentration in volunteer's saliva, without changing salivary pH values.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.