Evidence map›Paper›PMID 27490242›Full record

ArticlePloS one2016

Prevalence and Phylogenetic Analysis of Human Bocaviruses 1-4 in Pediatric Patients with Various Infectious Diseases.

Min Zhao, Runan Zhu, Yuan Qian, Jie Deng, Fang Wang, Yu Sun, Huijin Dong, Liying Liu, Liping Jia, Linqing Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Min ZhaoKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Runan ZhuKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Yuan QianKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Jie DengKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Fang WangKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Yu SunKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Huijin DongKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Liying LiuKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Liping JiaKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Linqing ZhaoKey Beijing Laboratory of Viral Disease Etiology, Laboratory of Virology, Capital Institute of Pediatrics, Beijing, China.
Capital Institute of Pediatrics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesViral infections caused by human bocaviruses 1-4 (HBoV1-4) are more complicated than previously believed. A retrospective, large-scale study was undertaken to explore the prevalence of HBoV1-4 in pediatric patients with various infectious diseases and delineate their phylogenetic characteristics.

methodsClinical samples from four specimen types, including 4,941 respiratory, 2,239 cerebrospinal fluid (CSF), 2,619 serum, and 1,121 fecal specimens, collected from pediatric patients with various infectious diseases were screened for HBoV1-4. A 690-nt fragment in each specimen was then amplified and sequenced for phylogenetic analysis. Clinical characteristics of HBoV-positive patients with different specimen types available were evaluated.

resultsApproximately 1.2% of patients were confirmed as HBoV-positive, with the highest positive rate in patients with gastrointestinal infection (2.2%), followed by respiratory (1.65%), central nervous system (0.8%), and hematological infections (0.2%). A single genetic lineage of HBoV1 circulated among children over the 8-year period, while a new cluster of HBoV2, via intra-genotype recombination between HBoV2A and HBoV2B, was prevalent. Some patients had HBoV1-positive respiratory and serum specimens or fecal specimens. Several cases became HBoV1-positive following the appearance of respiratory infection, while several cases were positive for HBoV2 only in CSF and serum specimens, rather than respiratory specimens.

conclusionsA single genetic lineage of HBoV1 is speculated as a viral pathogen of respiratory infection and causes both comorbid infection and acute gastroenteritis. Additionally, a new cluster of HBoV2 is prevalent in China, which may infect the host through sites other than the respiratory tract.

Indexed as

PhylogenyAdolescentChildChild, PreschoolDNA, ViralFecesFemaleGastroenteritisGenetic LinkageGenotypeHuman bocavirusHumansInfantInfant, NewbornMaleParvoviridae InfectionsDNA, Viral

Identifiers

PMID27490242
PMCPMC4973976
OpenAlexW2493869099

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.