ReviewCurrent opinion in allergy and clinical immunology2016
Epidemiology of severe anaphylaxis: can we use population-based data to understand anaphylaxis?
Review in Current opinion in allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Global patterns in anaphylaxis due to specific foods: A systematic review.The Journal of allergy and clinical immunology · 2021Pooled it
- Food allergy: begin at the skin, end at the mast cell?Nature reviews. Immunology · 2025Review
- Review
- Adrenaline Auto-Injectors for Preventing Fatal Anaphylaxis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- Fatal food anaphylaxis in adults and children.Italian journal of pediatrics · 2024Review
- Refractory Anaphylaxis: A New Entity for Severe Anaphylaxis.The journal of allergy and clinical immunology. In practice · 2023Review
- Evaluation of the triggers and the treatment models of anaphylaxis in pediatric patients.Northern clinics of Istanbul · 2023Article
- Children at risk of anaphylaxis: A mixed-studies systematic review of parents' experiences and information needs.PEC innovation · 2022Review
- Emergency department childhood anaphylaxis presentations in regional/remote Australia.Journal of paediatrics and child health · 2022Article
- Emergency treatment of anaphylaxis: concise clinical guidance.Clinical medicine (London, England) · 2022Article
- Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis.JCI insight · 2022Article
- Anaphylaxis knowledge gaps and future research priorities: A consensus report.The Journal of allergy and clinical immunology · 2022Article
- Article
- CSACI position statement: transition recommendations on existing epinephrine autoinjectors.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Food labeling issues for severe food allergic patients.The World Allergy Organization journal · 2021Review
- Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018.BMJ (Clinical research ed.) · 2021Article
- Cardiovascular changes during peanut-induced allergic reactions in human subjects.The Journal of allergy and clinical immunology · 2021Observational
- Emerging Causes of Drug-Induced Anaphylaxis: A Review of Anaphylaxis-Associated Reports in the FDA Adverse Event Reporting System (FAERS).The journal of allergy and clinical immunology. In practice · 2021Review
- Increasing anaphylaxis events in Western Australia identified using four linked administrative datasets.The World Allergy Organization journal · 2020Article
- Reaction phenotypes in IgE-mediated food allergy and anaphylaxis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
purpose of reviewThe observed increase in incidence of allergic disease in many regions over the past 3 decades has intensified interest in understanding the epidemiology of severe allergic reactions. We discuss the issues in collecting and interpreting these data and highlight current deficiencies in the current methods of data gathering. RECENT
findingsAnaphylaxis, as measured by hospital admission rates, is not uncommon and has increased in the United Kingdom, the United States, Canada, and Australia over the last 10-20 years. All large datasets are hampered by a large proportion of uncoded, 'unspecified' causes of anaphylaxis. Fatal anaphylaxis remains a rare event, but appears to be increasing for medication in Australia, Canada, and the United States. The rate of fatal food anaphylaxis is stable in the United Kingdom and the United States, but has increased in Australia. The age distribution for fatal food anaphylaxis is different to other causes, with data suggesting an age-related predisposition to fatal outcomes in teenagers and adults to the fourth decade of life. SUMMARY: The increasing rates of food and medication allergy (the latter exacerbated by an ageing population) has significant implications for future fatality trends. An improved ability to accurately gather and analyse population-level anaphylaxis data in a harmonized fashion is required, so as to ultimately minimize risk and improve management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.