ArticleGenetics in medicine : official journal of the American College of Medical Genetics2017
Modeling the prevention of colorectal cancer from the combined impact of host and behavioral risk factors.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Pooled it
- Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.Gastroenterology · 2019Pooled it
- Integrated analysis identifies an immune-based prognostic signature for the mesenchymal identity in colorectal cancer.Medicine · 2020Trial
- Dual-attention bidirectional LSTM with feature genomic analysis improves prognostic survival prediction in colorectal cancer patients.Journal of the Egyptian National Cancer Institute · 2026Article
- Comprehensive identification of hub mRNAs and lncRNAs in colorectal cancer using galaxy: an in silico transcriptome analysis.Discover oncology · 2025Article
- Chemopreventive Effects of Statins and Aspirin on Colorectal Cancer Among Patients with Inflammatory Bowel Disease: Evidence of a Synergistic Association from a Large Cohort.Clinical and experimental gastroenterology · 2025Article
- The global, regional, and national burden of colorectal cancer and its attributable risk factors in 204 countries and territories, 1990-2021: a systematic analysis for the global burden of disease study 2021.Frontiers in oncology · 2025Article
- Fluorescence-guided tumor visualization of colorectal cancer using tumor-initiating probe yellow in preclinical models.Scientific reports · 2024Article
- Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence.BMC medical genomics · 2023Article
- Global, regional, and national burden of colorectal cancer and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.The lancet. Gastroenterology & hepatology · 2022Article
- Identification and validation of an inflammation-related lncRNAs signature for improving outcomes of patients in colorectal cancer.Frontiers in genetics · 2022Article
- Establishment and experimental validation of an immune miRNA signature for assessing prognosis and immune landscape of patients with colorectal cancer.Journal of cellular and molecular medicine · 2021Article
- Will polygenic risk scores for cancer ever be clinically useful?NPJ precision oncology · 2021Article
- Identification of Vitamin D-related gene signature to predict colorectal cancer prognosis.PeerJ · 2021Article
- The Emerging Landscape of Long Non-Coding RNAs in Colorectal Cancer Metastasis.Frontiers in oncology · 2021Review
- Ultra-Processed Food Intake and Smoking Interact in Relation with Colorectal Adenomas.Nutrients · 2020Article
- The Impact of a Comprehensive Risk Prediction Model for Colorectal Cancer on a Population Screening Program.JNCI cancer spectrum · 2020Article
- Assessing thyroid cancer risk using polygenic risk scores.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification of an Immune-Related Gene Signature to Improve Prognosis Prediction in Colorectal Cancer Patients.Frontiers in genetics · 2020Article
- Metabolic models predict bacterial passengers in colorectal cancer.Cancer & metabolism · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThis study investigated the utility of modeling modifiable lifestyle risk factors in addition to genetic variation in colorectal cancer (CRC) screening/prevention.
methodsWe derived a polygenic risk score for CRC susceptibility variants in combination with the established nongenetic risk factors of inflammatory bowel disease (IBD), adiposity, alcohol, red meat, fruit, vegetables, smoking, physical activity, and aspirin. We used the 37 known risk variants and 50 and 100% of all risk variants as calculated from a heritability estimate. We derived absolute risk from UK population age structure, incidence, and mortality rate data.
resultsTaking into account all risk factors (known variants), 42.2% of 55- to 59-year-old men with CRC have a risk at least as high as that of an average 60-year-old, the minimum eligible age for the UK NHS National Bowel Cancer Screening Program. If the male population is stratified by known variants and IBD status, then risk-difference estimates imply that for 10,000 50-year-old men in the 99th percentile, 760 cases could be prevented over a 25-year period through the modifiable risk factors, but in the lowest percentile, only 90 could be prevented.
conclusionCRC screening and prevention centered on modifiable risk factors could be optimized if targeted at individuals at higher polygenic risk.Genet Med 19 3, 314-321.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.