ReviewPLoS neglected tropical diseases2016
Transmission or Within-Host Dynamics Driving Pulses of Zoonotic Viruses in Reservoir-Host Populations.
Review in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 4 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- Temporal and spatial limitations in global surveillance for bat filoviruses and henipaviruses.Biology letters · 2019Pooled it
- Prioritizing surveillance of Nipah virus in India.PLoS neglected tropical diseases · 2019Pooled it
- The non-human reservoirs of Ross River virus: a systematic review of the evidence.Parasites & vectors · 2018Pooled it
- Handling Stress and Sample Storage Are Associated with Weaker Complement-Mediated Bactericidal Ability in Birds but Not Bats.Physiological and biochemical zoology : PBZPooled it
- Periodic shifts in viral load increase risk of Hendra virus spillover fromScience advances · 2026Article
- Nipah Virus Shedding in Urine from Fruit Bats, Sri Lanka, 2018-2019.Emerging infectious diseases · 2026Article
- Article
- Spatio-temporal dynamics of Hendra virus in Australia reveal stable maintenance of diverse viral clades among Pteropus bats.Nature microbiology · 2026Article
- Article
- Cohorts of immature Pteropus bats show interannual variation in Hendra virus serology.The Journal of animal ecology · 2026Article
- A general framework for modeling pathogen transmission in co-roosting host communities.Ecology · 2026Article
- A risk-gate mechanistic-ecological framework for assessing emergence potential of henipa-related viruses.Frontiers in microbiology · 2026Article
- Systemic Effects of Pesticides on Insectivorous Bats: A Proteomics Approach.Integrative and comparative biology · 2025Article
- Evaluation of a Probe-Based Enrichment Protocol for Nanopore Sequencing of Zoonotic Viruses.Viruses · 2025Article
- New Coronavirus in Colombian Caribbean Bats: In Silico Analysis Reveals Possible Risk of Interspecific Jumping.Viruses · 2025Article
- Evaluation of long-term immunity following inoculation with highly diverse orthomarburgvirus isolates in Egyptian rousette bats (Journal of virology · 2025Article
- Viral ecology in chiroptera: human-wildlife interactions and pandemic risk.Veterinary research communications · 2025Review
- Role of individual and population heterogeneity in shaping dynamics of multi-pathogen shedding in an island endemic bat.PLoS pathogens · 2025Article
- A One Health approach to understanding and managing Nipah virus outbreaks.Nature microbiology · 2025Review
- Where is the elusive primaryBioscience · 2025Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
Progress in combatting zoonoses that emerge from wildlife is often constrained by limited knowledge of the biology of pathogens within reservoir hosts. We focus on the host-pathogen dynamics of four emerging viruses associated with bats: Hendra, Nipah, Ebola, and Marburg viruses. Spillover of bat infections to humans and domestic animals often coincides with pulses of viral excretion within bat populations, but the mechanisms driving such pulses are unclear. Three hypotheses dominate current research on these emerging bat infections. First, pulses of viral excretion could reflect seasonal epidemic cycles driven by natural variations in population densities and contact rates among hosts. If lifelong immunity follows recovery, viruses may disappear locally but persist globally through migration; in either case, new outbreaks occur once births replenish the susceptible pool. Second, epidemic cycles could be the result of waning immunity within bats, allowing local circulation of viruses through oscillating herd immunity. Third, pulses could be generated by episodic shedding from persistently infected bats through a combination of physiological and ecological factors. The three scenarios can yield similar patterns in epidemiological surveys, but strategies to predict or manage spillover risk resulting from each scenario will be different. We outline an agenda for research on viruses emerging from bats that would allow for differentiation among the scenarios and inform development of evidence-based interventions to limit threats to human and animal health. These concepts and methods are applicable to a wide range of pathogens that affect humans, domestic animals, and wildlife.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.