ReviewCommunicative & integrative biology
Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution.
Review in Communicative & integrative biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Luteinizing Hormone Regulation of Inter-Organelle Communication and Fate of the Corpus Luteum.International journal of molecular sciences · 2021Review
- TMEM16K is an interorganelle regulator of endosomal sorting.Nature communications · 2020Article
- Glycolipids: Linchpins in the Organization and Function of Membrane Microdomains.Frontiers in cell and developmental biology · 2020Review
- Readily Releasable Stores of Calcium in Neuronal Endolysosomes: Physiological and Pathophysiological Relevance.Advances in experimental medicine and biology · 2020Review
- Role of endolysosomes and pH in the pathogenesis and treatment of glioblastoma.Cancer reports (Hoboken, N.J.) · 2019Article
- Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer's disease.Brain research · 2019Review
- BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation.Scientific reports · 2019Article
- An equal opportunity collaboration between lipid metabolism and proteins in the control of membrane trafficking in the trans-Golgi and endosomal systems.Current opinion in cell biology · 2019Review
- Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer.Frontiers in cell and developmental biology · 2019Review
- SNX14 mutations affect endoplasmic reticulum-associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20.Human molecular genetics · 2018Article
- Emptying the stores: lysosomal diseases and therapeutic strategies.Nature reviews. Drug discovery · 2018Review
- Lipid droplet biogenesis is spatially coordinated at ER-vacuole contacts under nutritional stress.EMBO reports · 2018Article
- Ascorbate peroxidase proximity labeling coupled with biochemical fractionation identifies promoters of endoplasmic reticulum-mitochondrial contacts.The Journal of biological chemistry · 2017Article
- Discovery and Roles of ER-Endolysosomal Contact Sites in Disease.Advances in experimental medicine and biology · 2017Review
- Lysosomal Calcium in Neurodegeneration.Messenger (Los Angeles, Calif. : Print) · 2016Article
- Genetically Modified Cell Transplantation Through Macroencapsulated Spheroids with Scaffolds to Treat Fabry Disease.Cell transplantationArticle
- Remodelling of Nucleus-Vacuole Junctions During Metabolic and Proteostatic Stress.Contact (Thousand Oaks (Ventura County, Calif.))Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Since their initial observation, contact sites formed between different organelles have transitioned from ignored curiosities to recognized centers for the exchange of metabolites and lipids. Contact formed between the ER and endomembrane system (eg. the plasma membrane, endosomes, and lysosomes) is of particular biomedical interest, as it governs aspects of lipid metabolism, organelle identity, and cell signaling. Here, we review the field of ER-endolysosomal communication from the perspective of three model systems: budding yeast, the fruit fly D. melanogaster, and mammals. From this broad perspective, inter-organelle communication displays a consistent role in metabolic regulation that was differentially tuned during the development of complex metazoan life. We also examine the current state of understanding of lipid exchange between organelles, and discuss molecular mechanisms by which this occurs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.