ReviewFrontiers in endocrinology2016
Role of ACTH in the Interactive/Paracrine Regulation of Adrenal Steroid Secretion in Physiological and Pathophysiological Conditions.
Review in Frontiers in endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Pharmacokinetics, Pharmacodynamics and Immunogenicity of AC02, a Novel Synthetic Derivate Peptide of Human Adrenocorticotropic Hormone for Infantile Spasms.Pharmaceutics · 2026Article
- Weaning stress induced alterations to the hypothalamic-pituitary-thyroid and -adrenal axes in swine.Physiological reports · 2026Article
- Utility ofIrish veterinary journal · 2025Article
- Article
- Adrenocorticotropin-Secreting Pure Adrenal Ganglioneuroma Leading to Cushing Syndrome.JCEM case reports · 2025Article
- Article
- Evidence of the Role of Inflammation and the Hormonal Environment in the Pathogenesis of Adrenal Myelolipomas in Congenital Adrenal Hyperplasia.International journal of molecular sciences · 2024Article
- Distinct serum steroid profiles between adrenal Cushing syndrome and Cushing disease.Frontiers in endocrinology · 2023Article
- Whole-genome sequence analysis reveals selection signatures for important economic traits in Xiang pigs.Scientific reports · 2022Article
- Vascular and hormonal interactions in the adrenal gland.Frontiers in endocrinology · 2022Review
- Cushing's syndrome caused by intra-adrenocortical adrenocorticotropic hormone in a dog.Journal of veterinary internal medicine · 2022Article
- Mixed Corticomedullary Tumor Accompanied by Unilateral Aldosterone-Producing Adrenocortical Micronodules: a Case Report.Journal of the Endocrine Society · 2021Article
- Article
- Novel function of adrenocorticotropic hormone in the stimulation of vascular endothelial growth factor release in healthy children and adolescents: a proof-of-concept study.Annals of pediatric endocrinology & metabolism · 2021Article
- Cosyntropin stimulation in adrenal vein sampling improves the judgment of successful adrenal vein catheterization and outcome prediction for primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- From ACTH-Dependent to ACTH-Independent Cushing's Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells.Case reports in endocrinology · 2020Article
- Article
- Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls.Frontiers in psychiatry · 2018Article
- Hypothalamic-Pituitary-Adrenal Axis Modulation of Glucocorticoids in the Cardiovascular System.International journal of molecular sciences · 2017Review
- Signatures of Selection and Interspecies Introgression in the Genome of Chinese Domestic Pigs.Genome biology and evolution · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the normal human adrenal gland, steroid secretion is regulated by a complex network of autocrine/paracrine interactions involving bioactive signals released by endothelial cells, nerve terminals, chromaffin cells, immunocompetent cells, and adrenocortical cells themselves. ACTH can be locally produced by medullary chromaffin cells and is, therefore, a major mediator of the corticomedullary functional interplay. Plasma ACTH also triggers the release of angiogenic and vasoactive agents from adrenocortical cells and adrenal mast cells and, thus, indirectly regulates steroid production through modulation of the adrenal blood flow. Adrenocortical neoplasms associated with steroid hypersecretion exhibit molecular and cellular defects that tend to reinforce the influence of paracrine regulatory loops on corticosteroidogenesis. Especially, ACTH has been found to be abnormally synthesized in bilateral macronodular adrenal hyperplasia responsible for hypercortisolism. In these tissues, ACTH is detected in a subpopulation of adrenocortical cells that express gonadal markers. This observation suggests that ectopic production of ACTH may result from impaired embryogenesis leading to abnormal maturation of the adrenogonadal primordium. Globally, the current literature indicates that ACTH is a major player in the autocrine/paracrine processes occurring in the adrenal gland in both physiological and pathological conditions.
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