Evidence map›Paper›PMID 27489531›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2016

Metabolomics connects aberrant bioenergetic, transmethylation, and gut microbiota in sarcoidosis.

Andreea Geamanu, Smiti V Gupta, Christian Bauerfeld, Lobelia Samavati

Open access · greenAbstract read
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Metabolomic signaling in sarcoidosis pathogenesis.Current opinion in immunology · 2026
    Review
  4. Article
  5. Sarcoidosis Resolvers and Progressors Demonstrate Distinct Systemic Metabolomic Profiles.American journal of respiratory and critical care medicine · 2025
    Article
  6. Article
  7. Article
  8. ERJ open research · 2025
    Article
  9. Overview of multi-omics approaches for pulmonary sarcoidosis.EC pulmonology and respiratory medicine · 2025
    Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Macrophage Biology in Human Granulomatous Skin Inflammation.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Andreea GeamanuDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Wayne State University School of Medicine and Detroit Medical Center, 3990 John R., 3 Hudson, Detroit, MI 48201, USA.
Smiti V GuptaDepartment of Nutrition and Food Science, Wayne State University, Detroit, MI 48201, USA.
Christian BauerfeldDivision of Pediatric Critical Care, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI 48201, USA.
Lobelia SamavatiDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Wayne State University School of Medicine and Detroit Medical Center, 3990 John R., 3 Hudson, Detroit, MI 48201, USA; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Wayne State University · USChildren's Hospital of Michigan · USDetroit Medical Center · US

Funding

Role and Regulation of MKP-1 in SarcoidosisR01HL113508 · NHLBI · WAYNE STATE UNIVERSITY · PI SAMAVATI, LOBELIA · 2013 to 2017
$1.9M
NHLBI NIH HHS R01 HL113508
6 · The paper itself

Abstract

Sarcoidosis is a systemic granulomatous disease of unknown etiology. Granulomatous inflammation in sarcoidosis may affect multiple organs, including the lungs, skin, CNS, and the eyes, leading to severe morbidity and mortality. The underlying mechanisms for sustained inflammation in sarcoidosis are unknown. We hypothesized that metabolic changes play a critical role in perpetuation of inflammation in sarcoidosis.

Indexed as

1H NMRMetabolomicsSarcoidosisTCA cycleβ-Oxidation

Identifiers

PMID27489531
PMCPMC4960975
OpenAlexW2285059687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.