Evidence map›Paper›PMID 27489371›Full record

ArticleJournal of neurophysiology2016

Effect of phenytoin on sodium conductances in rat hippocampal CA1 pyramidal neurons.

Zhen Zeng, Elisa L Hill-Yardin, David Williams, Terence O'Brien, Andris Serelis, Christopher R French

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Journal of neurophysiology · 2022
    Article
  4. Article
  5. Article
  6. Phenytoin: neuroprotection or neurotoxicity?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhen ZengDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Elisa L Hill-YardinDepartment of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
David WilliamsDepartment of Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Terence O'BrienDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia; and.
Andris SerelisDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Christopher R FrenchDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia; Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia; and frenchc@unimelb.edu.au.
University of Melbourne · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antiepileptic drug phenytoin (PHT) is thought to reduce the excitability of neural tissue by stabilizing sodium channels (Na

Indexed as

AnimalsAnticonvulsantsCA1 Region, HippocampalComputer SimulationDose-Response Relationship, DrugFemaleMaleMembrane PotentialsModels, NeurologicalPatch-Clamp TechniquesPhenytoinPyramidal CellsRats, WistarSodiumSodium ChannelsTissue Culture TechniquesAnticonvulsantsPhenytoinSodiumSodium ChannelsVoltage-Gated Sodium Channel BlockersCA1hippocampusphenytoinrat

Identifiers

PMID27489371
PMCPMC5144711
OpenAlexW2503874527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.