Evidence map›Paper›PMID 27489209›Full record

ArticleG3 (Bethesda, Md.)2016

Cross-Validation Without Doing Cross-Validation in Genome-Enabled Prediction.

Daniel Gianola, Chris-Carolin Schön

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. AdaptiveGS: an explainable genomic selection framework based on adaptive stacking ensemble machine learning.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Article
  2. Rapid cycling genomic selection in maize landraces.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Article
  3. Article
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  8. Genomic Prediction: Progress and Perspectives for Rice Improvement.Methods in molecular biology (Clifton, N.J.) · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Validation of single-step GBLUP genomic predictions from threshold models using the linear regression method: An application in chicken mortality.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2021
    Article
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  15. Review
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  18. Combining pedigree and genomic information to improve prediction quality: an example in sorghum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel GianolaDepartment of Animal Sciences, University of Wisconsin-Madison, Wisconsin 53706 Department of Dairy Science, University of Wisconsin-Madison, Wisconsin 53706 Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Wisconsin 53706 Department of Plant Sciences, Technical University of Munich School of Life Sciences, Technical University of Munich, Garching, Germany Institute of Advanced Study, Technical University of Munich, Garching, Germany gianola@ansci.wisc.edu.ORCID 0000-0001-8217-2348
Chris-Carolin SchönDepartment of Plant Sciences, Technical University of Munich School of Life Sciences, Technical University of Munich, Garching, Germany Institute of Advanced Study, Technical University of Munich, Garching, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cross-validation of methods is an essential component of genome-enabled prediction of complex traits. We develop formulae for computing the predictions that would be obtained when one or several cases are removed in the training process, to become members of testing sets, but by running the model using all observations only once. Prediction methods to which the developments apply include least squares, best linear unbiased prediction (BLUP) of markers, or genomic BLUP, reproducing kernels Hilbert spaces regression with single or multiple kernel matrices, and any member of a suite of linear regression methods known as "Bayesian alphabet." The approach used for Bayesian models is based on importance sampling of posterior draws. Proof of concept is provided by applying the formulae to a wheat data set representing 599 inbred lines genotyped for 1279 markers, and the target trait was grain yield. The data set was used to evaluate predictive mean-squared error, impact of alternative layouts on maximum likelihood estimates of regularization parameters, model complexity, and residual degrees of freedom stemming from various strengths of regularization, as well as two forms of importance sampling. Our results will facilitate carrying out extensive cross-validation without model retraining for most machines employed in genome-assisted prediction of quantitative traits.

Indexed as

GenomeGenomicsModels, GeneticAlgorithmsBayes TheoremGenetic Association StudiesGenome-Wide Association StudyModels, StatisticalRegression AnalysisReproducibility of Resultscross-validationgenomic BLUPgenomic predictiongenomic selectionGenPredreproducing kernelsShared Data Resources

Identifiers

PMID27489209
PMCPMC5068934

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.