ArticlePediatric diabetes2017
Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure.
Article in Pediatric diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes.Diabetes care · 2020Trial
- Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis.The New England journal of medicine · 2018Trial
- Clinical analysis of 20 cases of brain injury caused by diabetic ketoacidosis in children.BMC pediatrics · 2025Article
- Associations between type 1 diabetes and educational outcomes: an Aotearoa/New Zealand nationwide birth cohort study using the Integrated Data Infrastructure.Diabetologia · 2024Article
- Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?Therapeutic advances in chronic disease · 2024Review
- Understanding Providers' Readiness and Attitudes Toward Autoantibody Screening: A Mixed-Methods Study.Clinical diabetes : a publication of the American Diabetes Association · 2024Article
- Nonketotic hyperglycemic hemichorea-hemiballismus in a pediatric patient: A case report.Clinical case reports · 2023Article
- Effects of the timing of the initiation of dietary intake on pediatric type 1 diabetes for diabetic ketoacidosis.BMC pediatrics · 2022Article
- Association of Type 1 Diabetes and Hypoglycemic and Hyperglycemic Events and Risk of Dementia.Neurology · 2021Article
- Parent and Pediatrician Preferences for Type 1 Diabetes Screening in the U.S.Diabetes care · 2021Article
- Article
- Recurrent diabetic ketoacidosis and cognitive function among older adults with type 1 diabetes: findings from the Study of Longevity in Diabetes.BMJ open diabetes research & care · 2020Article
- DIABETIC KETOACIDOSIS AS THE INITIAL PRESENTATION OF TYPE 1 DIABETES IN CHILDREN AND ADOLESCENTS: EPIDEMIOLOGICAL STUDY IN SOUTHERN BRAZIL.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020Article
- Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus.Frontiers in endocrinology · 2020Review
- Executive task-based brain function in children with type 1 diabetes: An observational study.PLoS medicine · 2019Observational
- Impact of Early Diabetic Ketoacidosis on the Developing Brain.Diabetes care · 2019Observational
- Observational
- Prefronto-temporal white matter microstructural alterations 20 years after the diagnosis of type 1 diabetes mellitus.Pediatric diabetes · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDifferences in cognition and brain structure have been found in youth with type 1 diabetes compared with controls, even after relatively short disease duration. To determine whether severity of clinical presentation contributes to these differences, we obtained structural magnetic resonance imaging (MRI) scans in youth ages 7-17 who were either newly diagnosed with type 1 diabetes (<3.5 months from diagnosis, n = 46) or a sibling without diabetes (n = 28). RESEARCH DESIGN AND
methodsSeverity of presentation was measured by the presence of diabetic ketoacidosis (DKA) and degree of hyperglycemia exposure [hemoglobin A1c (HbA1c)] at diagnosis. MRI were obtained using T1-weighted, T2-weighted, and diffusion-weighted sequences.
resultsWithin the group with type 1 diabetes, 12 subjects presented in DKA and 34 did not. After controlling for age, sex, and multiple comparisons, the type 1 diabetes group had lower volume in the left temporal-parietal-occipital cortex compared with controls. Within the type 1 diabetes group, DKA at presentation was associated with lower radial, axial, and mean diffusivity (MD) throughout major white matter tracts and higher HbA1c was associated with lower hippocampal, thalamic, and cerebellar white matter volumes, lower right posterior parietal cortical thickness, and greater right occipital cortical thickness.
conclusionThese data suggest that severity of clinical presentation is an important factor in predicting brain structural differences in youth with type 1 diabetes approximately 3 months after diagnosis.
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Registered trials
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