ArticleEBioMedicine2016
Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem.
Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Absence of human yaws and detection of Haemophilus ducreyi in skin ulcers of school children near wildlife protected areas in Tanzania.PLoS neglected tropical diseases · 2026Article
- Detection of Haemophilus ducreyi from environmental and animal samples in Cameroon.PLoS neglected tropical diseases · 2025Article
- Whole-genome sequencing reveals evidence for inter-species transmission of the yaws bacterium among nonhuman primates in Tanzania.PLoS neglected tropical diseases · 2025Article
- High prevalence and genetic diversity ofMicrobiology spectrum · 2024Article
- The hare syphilis agent is related to, but distinct from, the treponeme causing rabbit syphilis.PloS one · 2024Article
- Article
- Review
- LAMP4yaws:BMJ open · 2022Article
- Towards an odour-baited trap to control Musca sorbens, the putative vector of trachoma.Scientific reports · 2021Article
- Geographically structured genomic diversity of non-human primate-infectingMicrobial genomics · 2020Article
- Serosurvey of Treponema pallidum infection among children with skin ulcers in the Tarangire-Manyara ecosystem, northern Tanzania.BMC infectious diseases · 2020Article
- Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates.Scientific reports · 2019Article
- Advances in the Treatment of Yaws.Tropical medicine and infectious disease · 2018Review
- Widespread Treponema pallidum Infection in Nonhuman Primates, Tanzania.Emerging infectious diseases · 2018Article
- Complete mitochondrial genome of an olive baboon (Mitochondrial DNA. Part B, Resources · 2018Article
- Article
- Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea.PLoS neglected tropical diseases · 2017Article
- Disease reservoirs: from conceptual frameworks to applicable criteria.Emerging microbes & infections · 2017Review
- Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea.PLoS neglected tropical diseases · 2017Article
- Flies and Yaws: Molecular Studies Provide New Insight.EBioMedicine · 2016Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 5 countries.
Funding
Abstract
backgroundRecently, the World Health Organization launched a campaign to eradicate the tropical disease yaws, caused by the bacterium Treponema pallidum subsp. pertenue; however, for decades researchers have questioned whether flies act as a vector for the pathogen that could facilitate transmission.
methodsA total of 207 fly specimens were trapped in areas of Africa in which T. pallidum-induced skin ulcerations are common in wild baboons; 88 flies from Tarangire National Park and 119 from Lake Manyara National Park in Tanzania were analyzed by PCR for the presence of T. pallidum DNA.
findingsWe report that in the two study areas, T. pallidum DNA was found in 17-24% of wild-caught flies of the order Diptera. Treponemal DNA sequences obtained from many of the flies match sequences derived from nearby baboon T. pallidum strains, and one of the fly species with an especially high prevalence of T. pallidum DNA, Musca sorbens, has previously been shown to transmit yaws in an experimental setting.
interpretationOur results raise the possibility that flies play a role in yaws transmission; further research is warranted, given how important understanding transmission is for the eradication of this disfiguring disease.
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