ArticleScientific reports2016
Sound tuning of amygdala plasticity in auditory fear conditioning.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Stress-Enhanced Fear Learning in Rodents: A Systematic Review and Meta-Analysis of Fear-Learning Sensitization After Severe Stress.Brain sciences · 2026Review
- Of rats and robots: A mutual learning paradigm.Journal of the experimental analysis of behavior · 2025Article
- Independence Threat or Interdependence Threat? The Focusing Effect on Social or Physical Threat Modulates Brain Activity.Brain sciences · 2024Article
- Timing of vagus nerve stimulation during fear extinction determines efficacy in a rat model of PTSD.Scientific reports · 2022Article
- Article
- Reciprocal connectivity between secondary auditory cortical field and amygdala in mice.Scientific reports · 2019Article
- Sensory sensitivity as a link between concussive traumatic brain injury and PTSD.Scientific reports · 2019Article
- An Emergent Discriminative Learning Is Elicited During Multifrequency Testing.Frontiers in neuroscience · 2019Article
- Septal and Hippocampal Neurons Contribute to Auditory Relay and Fear Conditioning.Frontiers in cellular neuroscience · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various auditory tones have been used as conditioned stimuli (CS) for fear conditioning, but researchers have largely neglected the effect that different types of auditory tones may have on fear memory processing. Here, we report that at lateral amygdala (LA) synapses (a storage site for fear memory), conditioning with different types of auditory CSs (2.8 kHz tone, white noise, FM tone) recruits distinct forms of long-term potentiation (LTP) and inserts calcium permeable AMPA receptor (CP-AMPAR) for variable periods. White noise or FM tone conditioning produced brief insertion (<6 hr after conditioning) of CP-AMPARs, whereas 2.8 kHz tone conditioning induced more persistent insertion (≥6 hr). Consistently, conditioned fear to 2.8 kHz tone but not to white noise or FM tones was erased by reconsolidation-update (which depends on the insertion of CP-AMPARs at LA synapses) when it was performed 6 hr after conditioning. Our data suggest that conditioning with different auditory CSs recruits distinct forms of LA synaptic plasticity, resulting in more malleable fear memory to some tones than to others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.