ArticleProceedings. Biological sciences2016
Seeing red to being red: conserved genetic mechanism for red cone oil droplets and co-option for red coloration in birds and turtles.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 88 citations in OpenAlex.
- Bird Community Colours Across Different Types of Habitat.Animals : an open access journal from MDPI · 2026Article
- Biochemical and Genomic Underpinnings of Carotenoid Colour Variation Across a Hybrid Zone Between South Asian Flameback Woodpeckers.Molecular ecology · 2025Article
- Bdh1l Gene Expression Is a Potential Molecular Factor in the Evolution of Carotenoid-Based Colour Diversity of Cichlid Fishes.Molecular ecology · 2025Article
- PseudoChecker2 and PseudoViz: automation and visualization of gene loss in the Genome Era.Bioinformatics advances · 2025Article
- Multiple Routes to Color Convergence in a Radiation of Neotropical Poison Frogs.Systematic biology · 2023Article
- Astaxanthin: Past, Present, and Future.Marine drugs · 2023Review
- Effects of Natural and Synthetic Astaxanthin on Growth, Body Color, and Transcriptome and Metabolome Profiles in the Leopard Coralgrouper (Animals : an open access journal from MDPI · 2023Article
- Aster la vista: Unraveling the biochemical basis of carotenoid homeostasis in the human retina.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- Seasonal but not sex-biased gene expression of the carotenoid ketolase,Royal Society open science · 2022Article
- Article
- Pterin-based pigmentation in animals.Biology letters · 2021Article
- Transcriptomic Analysis of Skin Color in Anole Lizards.Genome biology and evolution · 2021Article
- Testing the carotenoid-based sexual signalling mechanism by alteringProceedings. Biological sciences · 2020Article
- Expression levels of the tetratricopeptide repeat protein geneBiology letters · 2020Article
- Genetic architecture underlying changes in carotenoid accumulation during the evolution of the blind Mexican cavefish, Astyanax mexicanus.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2020Article
- Article
- Testosterone regulatesProceedings. Biological sciences · 2020Article
- Being red, blue and green: the genetic basis of coloration differences in the strawberry poison frog (Oophaga pumilio).BMC genomics · 2020Article
- Comparative transcriptomics reveals candidate carotenoid color genes in an East African cichlid fish.BMC genomics · 2020Article
- Plumage redness signals mitochondrial function in the house finch.Proceedings. Biological sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Avian ketocarotenoid pigments occur in both the red retinal oil droplets that contribute to colour vision and bright red coloration used in signalling. Turtles are the only other tetrapods with red retinal oil droplets, and some also display red carotenoid-based coloration. Recently, the CYP2J19 gene was strongly implicated in ketocarotenoid synthesis in birds. Here, we investigate CYP2J19 evolution in relation to colour vision and red coloration in reptiles using genomic and expression data. We show that turtles, but not crocodiles or lepidosaurs, possess a CYP2J19 orthologue, which arose via gene duplication before turtles and archosaurs split, and which is strongly and specifically expressed in the ketocarotenoid-containing retina and red integument. We infer that CYP2J19 initially functioned in colour vision in archelosaurs and conclude that red ketocarotenoid-based coloration evolved independently in birds and turtles via gene regulatory changes of CYP2J19 Our results suggest that red oil droplets contributed to colour vision in dinosaurs and pterosaurs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.