ArticleCancer research2016
Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.
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In one paragraph
Article in Cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 3% of its field
What it found
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.Journal of the National Cancer Institute · 2022Pooled it
- Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.Molecular psychiatry · 2021Pooled it
- Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.Nature genetics · 2019Pooled it
- Multi-trait association analysis reveals shared genetic architecture between lung cancer and cardiometabolic diseases.iScience · 2025Article
- Genetic variations in CYP2A6 predict efficacy of neoadjuvant letrozole concurrent with chemotherapy in locally advanced hormone receptor-positive breast cancer.Annals of medicine · 2025Article
- Novel CYP2A7/CYP2A6 germline hybrids associated with mutation burden in lung cancer revealed by whole-genome long-read sequencing.Scientific reports · 2025Article
- Development of an ADME gene signature for prognostic and therapeutic stratification in gastric cancer.Discover oncology · 2025Article
- CHRNA5-A3-B4, CYP2A6, and DBH Genetic Associations With Smoking Cessation Throughout Adulthood Within Two Longitudinal Studies of Women.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Integrating genetic and clinical data to predict lung cancer in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2024Article
- Genome-wide association study of maternal plasma metabolites during pregnancy.Cell genomics · 2024Article
- PharmVar GeneFocus: CYP2A6.Clinical pharmacology and therapeutics · 2024Review
- Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility.Cancer research · 2024Article
- The use of biomarkers to guide precision treatment for tobacco use.Addiction neuroscience · 2023Article
- Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank.Addiction (Abingdon, England) · 2023Article
- Contribution of Genetic Polymorphisms in Human Health.International journal of environmental research and public health · 2023Review
- Predicting nicotine metabolism across ancestries using genotypes.BMC genomics · 2022Article
- Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck.International journal of cancer · 2022Article
- Multiethnic Prediction of Nicotine Biomarkers and Association With Nicotine Dependence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
- Transferability of Ancestry-Specific and Cross-Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations.Clinical pharmacology and therapeutics · 2021Article
Corrections and comments
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Authors and funding
21 authors at 1 institution in 1 country.
Yesha M PatelDepartment of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
Sunghim L ParkDepartment of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
Younghun HanDepartment of Biomedical Data Science, Dartmouth College, Hanover, New Hampshire.
Lynne R WilkensEpidemiology Program, University of Hawai'i Cancer Center, Honolulu, Hawaii.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
Albert RosenbergerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany.
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Irene BrüskeHelmholtz Centre Munich, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany.
Angela RischDepartment of Molecular Biology, University of Salzburg, Salzburg, Austria.
Yongyue WeiNanjing Medical University School of Public Health, Nanjing, China.
David C ChristianiMassachusetts General Hospital, Boston, Massachusetts. Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
Paul BrennanGenetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
Richard HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
James McKayGenetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
John McLaughlinPublic Health Ontario, Toronto, Ontario, Canada.
Rayjean HungLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Sharon MurphyDepartment of Biochemistry Molecular Biology and Biophysics and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Daniel O StramDepartment of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
Christopher AmosDepartment of Biomedical Data Science, Dartmouth College, Hanover, New Hampshire.
Loïc Le MarchandEpidemiology Program, University of Hawai'i Cancer Center, Honolulu, Hawaii. loic@cc.hawaii.edu.
Massachusetts General Hospital · US
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MUNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V. · 1996 to 2024
$57.4MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MUntargeted Adductomics to Characterize Ethnic Differences in the Exposome of SmokersP01CA138338 · NCI · UNIVERSITY OF MINNESOTA · PI Sungshim Lani Park · 2010 to 2026
$33.4MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MTHE CAROTENE AND RETINOL EFFICACY TRIAL (CARET)U01CA063673 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 1994 to 2006
$13.0MTranslational studies of Hsp90 inhibitors in NSCLCP50CA090578 · NCI · DANA-FARBER CANCER INST · PI MEYERSON, MATTHEW L. · 2008 to 2012
$11.4MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MPROSTATE, LUNG, COLORECTAL, &OVARIAN CANCER SCREENINGN01CN025476 · CN · WESTAT, INC. · PI O'BRIEN, BARBARA B · 1992 to 2000
$7.9MGenome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6MCancer Research UK C1298/A8362Cancer Research UK C1298/A8780CCR NIH HHS N01 RC037004NCI NIH HHS K07 CA160753NCI NIH HHS N01 CN025404NCI NIH HHS N01 CN025476NCI NIH HHS N01 CN025511NCI NIH HHS N01 CN025512NCI NIH HHS N01 CN025513NCI NIH HHS N01 CN025514NCI NIH HHS N01 CN025515NCI NIH HHS N01 CN025516NCI NIH HHS N01 CN025518NCI NIH HHS N01 CN025522NCI NIH HHS N01 CN025524NCI NIH HHS N01 CN045165NCI NIH HHS N01 CN075022NCI NIH HHS P01 CA138338NCI NIH HHS P20 CA090578NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA070907NCI NIH HHS P50 CA090578NCI NIH HHS R01 CA055769NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092039NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA111703NCI NIH HHS R01 CA121197NCI NIH HHS R01 CA127219NCI NIH HHS R01 CA133996NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA063673NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148127NCI NIH HHS UM1 CA167462NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446Wellcome TrustWorld Health Organization 001
Abstract
Metabolism of nicotine by cytochrome P450 2A6 (CYP2A6) is a suspected determinant of smoking dose and, consequently, lung cancer risk. We conducted a genome-wide association study (GWAS) of CYP2A6 activity, as measured by the urinary ratio of trans-3'-hydroxycotinine and its glucuronide conjugate over cotinine (total 3HCOT/COT), among 2,239 smokers in the Multiethnic Cohort (MEC) study. We identified 248 CYP2A6 variants associated with CYP2A6 activity (P < 5 × 10
Indexed as
Genome-Wide Association StudyPolymorphism, Single NucleotideAgedCytochrome P-450 CYP2A6FemaleGenetic MarkersHumansLung NeoplasmsMaleMiddle AgedRiskSmokingCytochrome P-450 CYP2A6Genetic Markers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.