Evidence map›Paper›PMID 27488468›Full record

ArticleScientific reports2016

Oxidized Low-density Lipoprotein (ox-LDL) Cholesterol Induces the Expression of miRNA-223 and L-type Calcium Channel Protein in Atrial Fibrillation.

Fengping He, Xin Xu, Shuguo Yuan, Liangqiu Tan, Lingjun Gao, Shaochun Ma, Shebin Zhang, Zhanzhong Ma, Wei Jiang, Fenglian Liu and 5 more

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Fengping HeDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Xin XuDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Shuguo YuanDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Liangqiu TanDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Lingjun GaoDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Shaochun MaDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Shebin ZhangDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Zhanzhong MaDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Wei JiangDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Fenglian LiuDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Baofeng ChenDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Beibei ZhangDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Jungang PangDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Xiuyan HuangDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Jiaqiang WengDepartment Institute of Cardiovascular Diseases, The Yuebei People's Hospital, Medical College, Shantou University, Shantou, Guangdong, China.
Yue Bei People's Hospital · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia causing high morbidity and mortality. While changing of the cellular calcium homeostasis plays a critical role in AF, the L-type calcium channel α1c protein has suggested as an important regulator of reentrant spiral dynamics and is a major component of AF-related electrical remodeling. Our computational modeling predicted that miRNA-223 may regulate the CACNA1C gene which encodes the cardiac L-type calcium channel α1c subunit. We found that oxidized low-density lipoprotein (ox-LDL) cholesterol significantly up-regulates both the expression of miRNA-223 and L-type calcium channel protein. In contrast, knockdown of miRNA-223 reduced L-type calcium channel protein expression, while genetic knockdown of endogenous miRNA-223 dampened AF vulnerability. Transfection of miRNA-223 by adenovirus-mediated expression enhanced L-type calcium currents and promoted AF in mice while co-injection of a CACNA1C-specific miR-mimic counteracted the effect. Taken together, ox-LDL, as a known factor in AF-associated remodeling, positively regulates miRNA-223 transcription and L-type calcium channel protein expression. Our results implicate a new molecular mechanism for AF in which miRNA-223 can be used as an biomarker of AF rheumatic heart disease.

Indexed as

AdultAgedAnimalsAtrial FibrillationBiomarkersCalcium Channels, L-TypeDogsFemaleGene Expression ProfilingHumansLipoproteins, LDLMaleMiceMice, Inbred C57BLMicroRNAsMiddle AgedBiomarkersCACNA1C protein, humanCACNA1C protein, mouseCalcium Channels, L-TypeLipoproteins, LDLMicroRNAsMIR223, humanoxidized low density lipoprotein

Identifiers

PMID27488468
PMCPMC4973266
OpenAlexW2490910683

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.