Evidence map›Paper›PMID 27488388›Full record

ArticleEuropean journal of clinical pharmacology2016

Adherence to antidepressants among women and men described with trajectory models: a Swedish longitudinal study.

Ann-Charlotte Mårdby, Linus Schiöler, Karolina Andersson Sundell, Pernilla Bjerkeli, Eva Lesén, Anna K Jönsson

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Medication Adherence Trajectories: A Systematic Literature Review.Journal of managed care & specialty pharmacy · 2020
    Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Persistence as a Robust Indicator of Medication Adherence-Related Quality and Performance.International journal of environmental research and public health · 2021
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ann-Charlotte MårdbyResearch and Development, Sahlgrenska University Hospital, Röda Stråket 8, 413 45, Gothenburg, Sweden. lotta.mardby@gmail.com.
Linus SchiölerSection of Occupational and Environmental Medicine, Department of Public Health and Community Medicine at Institute of Medicine, University of Gothenburg, Box 100, 405 30, Gothenburg, Sweden.
Karolina Andersson SundellSection of Epidemiology and Social Medicine, Department of Public Health and Community Medicine at Institute of Medicine, University of Gothenburg, Box 453, 405 30, Gothenburg, Sweden.
Pernilla BjerkeliNordic School of Public Health, PO Box 421, 42140, Gothenburg, Sweden.
Eva LesénNordic Health Economics AB, Medicinaregatan 8B, 413 90, Gothenburg, Sweden.
Anna K JönssonDepartment of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, 581 85, Linköping, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study are to analyse adherence to antidepressant treatment over 2 years in Sweden among women and men who initiated treatment with citalopram and to identify groups at risk of non-adherence using trajectory models.

methodsThe study population, including individuals 18-85 years who initiated citalopram use between 1 July 2006 and 30 June 2007, was identified in the Swedish Prescribed Drug Register and followed for 2 years. Adherence was estimated with continuous measure of medication acquisition (CMA) and group-based trajectory modelling, a method which describes adherence patterns over time by estimating trajectories of adherence and the individual's probability of belonging to a specific trajectory.

resultsThe study population included 54,248 individuals, 64 % women. Mean CMA was 52 % among women and 50 % among men (p < 0.001). Five different adherence patterns (Trajectories) were identified. Similar proportion of women and men belonged to each Trajectory. Around 29 % of the women and 27 % of the men belonged to the Trajectory which showed full adherence throughout the 2-year study period. The other four Trajectories showed adherence that declined to different degrees and at different stages in time. Having low socioeconomic status was more common among individuals in Trajectories showing declining adherence than in the adherent Trajectory.

conclusionsUsing trajectory modelling, five Trajectories describing different patterns of adherence to citalopram treatment over time were identified. A large proportion discontinued treatment early and having low socioeconomic status increased the risk of being non-adherent.

Indexed as

Drug MonitoringModels, BiologicalAdultAgedAntidepressive AgentsCitalopramFemaleHumansLongitudinal StudiesMaleMiddle AgedSocial ClassSwedenAntidepressive AgentsCitalopramAntidepressantsGenderMedication adherenceSwedish prescribed drug registerTrajectory models

Identifiers

PMID27488388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.