SynthesisSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Transient elastography in clinical detection of liver cirrhosis: A systematic review and meta-analysis.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection.Hepatology (Baltimore, Md.) · 2020Guideline
- Machine Learning-Based Biomarker Identification for Early Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease.The Journal of clinical endocrinology and metabolism · 2025Article
- Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.World journal of hepatology · 2025Article
- B-mode shear wave elastography can be an alternative method to vibration-controlled transient elastography according to a moderate-scale population study.Journal of medical ultrasonics (2001) · 2023Article
- Diagnostic Accuracy of Elastography and Liver Disease: A Meta-Analysis.Gastroenterology research · 2022Article
- Article
- Incidence and Risk Factors of Hepatic Fibrosis in Psoriatic Patients Receiving Methotrexate with Concomitant Acitretin Therapy and Methotrexate Monotherapy.Drug design, development and therapy · 2021Article
- Article
- Article
- Ultrasound Shear Wave Elastography as a Measure of Porcine Hepatic Disease in Right Heart Dysfunction: A Pilot Study.Ultrasound in medicine & biology · 2018Article
- Analysis of three ultrasound elastography techniques for grading liver fibrosis in patients with chronic hepatitis B.La Radiologia medica · 2018Article
- Hepatitis C virus infection in children in the era of direct-acting antiviral.World journal of gastroenterology · 2018Review
- Use of aspartate aminotransferase to platelet ratio to reduce the need for FibroScan in the evaluation of liver fibrosis.World journal of hepatology · 2017Article
- Elastography to assess the stage of liver fibrosis in children: Concepts, opportunities, and challenges.Clinical liver disease · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
BACKGROUND/
aimsTransient elastography is a noninvasive method for measuring liver fibrosis. This meta-analysis assesses the diagnostic performance of transient elastography of detecting liver cirrhosis in patients with liver disease. PATIENTS AND
methodsWe searched MEDLINE, Cochrane, EMBASE databases until Jan 31, 2015, using the following search terms: elastography and liver cirrhosis. Included studies assessed patients with a diagnosis of liver cirrhosis, with an index test of transient elastography, and with the reference standard being a histopathological exam by liver biopsy. Sensitivity analysis and assessment of risk of bias and publication bias were performed.
resultsFifty-seven studies were included in the meta-analysis with a total of 10,504 patients. The pooled estimate for the sensitivity of transient elastography for detecting liver fibrosis was 81% and the specificity was 88%. The imputed diagnostic odds ratio (DOR) was 26.08 and the area under the receiver-operating characteristic (AUROC) curve was 0.931.
conclusionOur findings indicate that transient elastography shows good sensitivity, specificity and a high accuracy for detecting liver cirrhosis. Transient elastography can be used as an additional method for the clinical diagnosis of liver fibrosis and cirrhosis.
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