ArticleBMC genomics2016
Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Description of Heterorhabditis americana n. sp. (Rhabditida, Heterorhabditidae), a new entomopathogenic nematode species isolated in North America.Parasites & vectors · 2025Article
- Photorhabdus viridis sp. nov. Isolated from Heterorhabditis zealandica Entomopathogenic Nematodes.Current microbiology · 2024Article
- Function and Global Regulation of Type III Secretion System and Flagella in Entomopathogenic Nematode Symbiotic Bacteria.International journal of molecular sciences · 2024Article
- Photorhabdus africana sp. nov. isolated from Heterorhabditis entomopathogenic nematodes.Current microbiology · 2024Article
- Antimicrobial Peptides (AMP) in the Cell-Free Culture Media ofAntibiotics (Basel, Switzerland) · 2023Article
- Selective Toxicity of Secondary Metabolites from the Entomopathogenic Bacterium Photorhabdus luminescensMicrobiology spectrum · 2022Article
- Article
- Biosynthesis of Sinapigladioside, an Antifungal Isothiocyanate from Burkholderia Symbionts.Chembiochem : a European journal of chemical biology · 2021Article
- Multi-locus phylogenetic analyses uncover species boundaries and reveal the occurrence of two new entomopathogenic nematode species,Journal of nematology · 2021Article
- Molecular mechanism of polyketide shortening in anthraquinone biosynthesis ofChemical science · 2019Article
- Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus.Nature microbiology · 2017Article
- Secondary Metabolites Produced byJournal of nematology · 2017Article
- Permanent Draft Genome Sequence ofGenome announcements · 2017Article
- Article
- Heterogeneous regulation of bacterial natural product biosynthesis via a novel transcription factor.Heliyon · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacteria within the genus Photorhabdus maintain mutualistic symbioses with nematodes in complicated lifecycles that also involves insect pathogenic phases. Intriguingly, these bacteria are rich in biosynthetic gene clusters that produce compounds with diverse biological activities. As a basis to better understand the life cycles of Photorhabdus we sequenced the genomes of two recently discovered representative species and performed detailed genomic comparisons with five publically available genomes.
resultsHere we report the genomic details of two new reference Photorhabdus species. By then conducting genomic comparisons across the genus, we show that there are several highly conserved biosynthetic gene clusters. These clusters produce a range of bioactive small molecules that support the pathogenic phase of the integral relationship that Photorhabdus maintain with nematodes.
conclusionsPhotorhabdus contain several genetic loci that allow them to become specialist insect pathogens by efficiently evading insect immune responses and killing the insect host.
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