Evidence map›Paper›PMID 27488237›Full record

ArticleThe American journal of clinical nutrition2016

Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men.

Aedín Cassidy, Monica Bertoia, Stephanie Chiuve, Alan Flint, John Forman, Eric B Rimm

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 11 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 11 syntheses or guidelines pooled it, 224 citations in OpenAlex.

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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Aedín CassidyDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, United Kingdom;
Monica BertoiaDepartments of Nutrition and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Stephanie ChiuveDepartments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Alan FlintDepartments of Nutrition and.
John FormanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Eric B RimmDepartments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA erimm@hsph.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USUniversity of East Anglia · GB

Funding

Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Biotechnology and Biological Sciences Research CouncilNCI NIH HHS UM1 CA167552
6 · The paper itself

Abstract

backgroundAlthough increased fruit intake reduces cardiovascular disease (CVD) risk, which fruits are most beneficial and what key constituents are responsible are unclear. Habitual intakes of flavonoids, specifically anthocyanins and flavanones, in which >90% of habitual intake is derived from fruit, are associated with decreased CVD risk in women, but associations in men are largely unknown.

objectiveWe examined the relation between habitual anthocyanin and flavanone intake and coronary artery disease and stroke in the Health Professionals Follow-Up Study.

designWe followed 43,880 healthy men who had no prior diagnosed CVD or cancer. Flavonoid intake was calculated with the use of validated food-frequency questionnaires.

resultsDuring 24 y of follow-up, 4046 myocardial infarction (MI) and 1572 stroke cases were confirmed by medical records. Although higher anthocyanin intake was not associated with total or fatal MI risk, after multivariate adjustment an inverse association with nonfatal MI was observed (HR: 0.87; 95% CI: 0.75, 1.00; P = 0.04; P-trend = 0.098); this association was stronger in normotensive participants (HR: 0.81; 95% CI: 0.69, 0.96; P-interaction = 0.03). Anthocyanin intake was not associated with stroke risk. Although flavanone intake was not associated with MI or total stroke risk, higher intake was associated with a lower risk of ischemic stroke (HR: 0.78; 95% CI: 0.62, 0.97; P = 0.03, P-trend = 0.059), with the greatest magnitude in participants aged ≥65 y (P-interaction = 0.04).

conclusionsHigher intakes of fruit-based flavonoids were associated with a lower risk of nonfatal MI and ischemic stroke in men. Mechanistic studies and clinical trials are needed to unravel the differential benefits of anthocyanin- and flavanone-rich foods on cardiovascular health.

Indexed as

Diet, HealthyFruitPatient ComplianceAdultAgedAged, 80 and overAnthocyaninsBrain IschemiaCohort StudiesFeeding BehaviorFlavanonesFollow-Up StudiesHealth PersonnelHumansMaleMiddle AgedAnthocyaninsFlavanonesanthocyaninsflavanonesflavonoidsheart diseasemenstroke

Identifiers

PMID27488237
PMCPMC4997299
OpenAlexW2477967355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.