Evidence map›Paper›PMID 27488220›Full record

ArticleCritical care medicine2016

Functional Status Score for the ICU: An International Clinimetric Analysis of Validity, Responsiveness, and Minimal Important Difference.

Minxuan Huang, Kitty S Chan, Jennifer M Zanni, Selina M Parry, Saint-Clair G B Neto, Jose A A Neto, Vinicius Z M da Silva, Michelle E Kho, Dale M Needham

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03604809 nacompletednot on this mapstarted 2019, after this paper: background citation

Guided Occupational Therapist Cognitive Interventions in Critically Ill Patients

TypeinterventionalSponsorAlberta Health Services, CalgaryRan2019 to 2020Enrolled70ConditionsDeliriumArmsOT Guided Cognitive Interventions
NCT04640441 nacompletednot on this mapstarted 2020, after this paper: background citation

Effect of Sit-to-Stand Intervention in the Intensive Care Unit Survivors: A Randomized Controlled Trial

TypeinterventionalSponsorNational Taiwan University HospitalRan2020 to 2024Enrolled246ConditionsUnable to Sit-to-stand, ICU SurvivorArmsSit-to-stand Intervention
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Guideline
  2. ICU-acquired weakness.Intensive care medicine · 2020
    Pooled it
  3. Pooled it
  4. A New Breathing Technique for Pain Management in Patients With Thoracic Trauma: A Randomised Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Trial
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  11. Observational
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  14. Perme Score and Machine Learning for Detecting ICU-acquired Weakness: A Prospective Observational Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
    Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Minxuan Huang1Outcome After Critical Illness and Surgery (OACIS) Group, Johns Hopkins University School of Medicine, Baltimore, MD.2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.3Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.4Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD.5Department of Physiotherapy, School of Health Sciences, University of Melbourne, Melbourne, VIC, Australia.6Department of Physical Therapy, Universidade Catolica de Brasilia, Brasilia, Brazil.7Department of Physical Therapy, Hospital Santa Luzia, Brasilia, Brazil.8Department of Research and Education, D'OR Institute, Brasilia, Brazil.9Health Sciences Program, Escola Superior de Ciencias da Saude, Brasilia, Brazil.10Department of Physical Therapy, Hospital de Base do Distrito Federal, Brasilia, Brazil.11School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Kitty S Chan
Jennifer M Zanni
Selina M Parry
Saint-Clair G B Neto
Jose A A Neto
Vinicius Z M da Silva
Michelle E Kho
Dale M Needham
Johns Hopkins University · USJohns Hopkins Medicine · USUniversity of Melbourne · AU

Funding

Improving Long-Term Outcomes Clinical Research for Acute Respiratory FailureR24HL111895 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NEEDHAM, DALE MURRAY · 2013 to 2017
$5.4M
NHLBI NIH HHS R24 HL111895
6 · The paper itself

Abstract

objectivesTo evaluate the internal consistency, validity, responsiveness, and minimal important difference of the Functional Status Score for the ICU, a physical function measure designed for the ICU.

designClinimetric analysis. SETTINGS: Five international datasets from the United States, Australia, and Brazil. PATIENTS: Eight hundred nineteen ICU patients.

interventionNone. MEASUREMENTS AND MAIN

resultsClinimetric analyses were initially conducted separately for each data source and time point to examine generalizability of findings, with pooled analyses performed thereafter to increase power of analyses. The Functional Status Score for the ICU demonstrated good to excellent internal consistency. There was good convergent and discriminant validity, with significant and positive correlations (r = 0.30-0.95) between Functional Status Score for the ICU and other physical function measures, and generally weaker correlations with nonphysical measures (|r| = 0.01-0.70). Known group validity was demonstrated by significantly higher Functional Status Score for the ICU scores among patients without ICU-acquired weakness (Medical Research Council sum score, ≥ 48 vs < 48) and with hospital discharge to home (vs healthcare facility). Functional Status Score for the ICU at ICU discharge predicted post-ICU hospital length of stay and discharge location. Responsiveness was supported via increased Functional Status Score for the ICU scores with improvements in muscle strength. Distribution-based methods indicated a minimal important difference of 2.0-5.0.

conclusionsThe Functional Status Score for the ICU has good internal consistency and is a valid and responsive measure of physical function for ICU patients. The estimated minimal important difference can be used in sample size calculations and in interpreting studies comparing the physical function of groups of ICU patients.

Indexed as

Intensive Care UnitsSeverity of Illness IndexActivities of Daily LivingAgedHumansLength of StayMiddle AgedPatient DischargeReproducibility of Results

Identifiers

PMID27488220
PMCPMC5292321
OpenAlexW2482543871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.