Evidence map›Paper›PMID 27488112›Full record

ArticleMetabolic brain disease2017

A longitudinal study of patients with cirrhosis treated with L-ornithine L-aspartate, examined with magnetization transfer, diffusion-weighted imaging and magnetic resonance spectroscopy.

Vijay P B Grover, Mark J W McPhail, Marzena Wylezinska-Arridge, Mary M E Crossey, Julie A Fitzpatrick, Louise Southern, Brian K Saxby, Nicola A Cook, I Jane Cox, Adam D Waldman and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Hepatic encephalopathy.Nature reviews. Disease primers · 2022
    Review
  3. Review
  4. Article
  5. Review
  6. Brain Edema in Chronic Hepatic Encephalopathy.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Vijay P B GroverLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Mark J W McPhailLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Marzena Wylezinska-ArridgeLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Mary M E CrosseyLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Julie A FitzpatrickLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Louise SouthernLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Brian K SaxbyCentre for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, UK.
Nicola A CookLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
I Jane CoxThe Foundation for Liver Research, Institute of Hepatology, 69-75 Chenies Mews, London, WC1E 6HX, UK.
Adam D WaldmanRobert Steiner MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, London, UK.
Novraj S DhanjalDivision of Brain Sciences, Hammersmith Hospital Campus, Imperial College London, London, UK.
Aluel Bak-BolLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
Roger WilliamsThe Foundation for Liver Research, Institute of Hepatology, 69-75 Chenies Mews, London, WC1E 6HX, UK.
Marsha Y MorganUCL Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, UK.
Simon D Taylor-RobinsonLiver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Wing, St Mary's Hospital, Praed Street, London, W2 1NY, UK. s.taylor-robinson@imperial.ac.uk.
Imperial College London · GBSt Mary's Hospital · GBFoundation for Liver Research · GBNewcastle Hospitals - Campus for Ageing and Vitality · GBUniversity College London · GB

Funding

Medical Research Council G0700528Wellcome Trust
6 · The paper itself

Abstract

The presence of overt hepatic encephalopathy (HE) is associated with structural, metabolic and functional changes in the brain discernible by use of a variety of magnetic resonance (MR) techniques. The changes in patients with minimal HE are less well documented. Twenty-two patients with well-compensated cirrhosis, seven of whom had minimal HE, were examined with cerebral 3 Tesla MR techniques, including T

Indexed as

AdultAgedBrainCognitionDiffusion Magnetic Resonance ImagingDipeptidesFemaleHepatic EncephalopathyHumansLiver CirrhosisMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedPsychometricsDipeptidesornithylaspartateCirrhosisHepatic encephalopathyMagnetic resonance imagingSpectroscopy

Identifiers

PMID27488112
PMCPMC5225223
OpenAlexW2487704348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.