ArticleBiology of reproduction2016
Sexually Dimorphic Gene Expression in Bovine Conceptuses at the Initiation of Implantation.
Article in Biology of reproduction, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Contributions of Artificial Intelligence Reported in Obstetrics and Gynecology Journals: Systematic Review.Journal of medical Internet research · 2022Pooled it
- Sexually dimorphic gene expression responses of bovine embryos to the maternal microenvironment on day 13 of gestation.BMC genomics · 2025Article
- An mRNA expression atlas for the duck with public RNA-seq datasets.BMC genomics · 2025Article
- The recipient metabolome explains the asymmetric ovarian impact on fetal sex development after embryo transfer in cattle.Journal of animal science · 2024Article
- Ruminant conceptus-maternal interactions: interferon-tau and beyond.Journal of animal science · 2022Review
- The influence of progesterone on bovine uterine fluid energy, nucleotide, vitamin, cofactor, peptide, and xenobiotic composition during the conceptus elongation-initiation window.Scientific reports · 2019Article
- Interferon tau-dependent and independent effects of the bovine conceptus on the endometrial transcriptome†.Biology of reproduction · 2019Article
- Associations between fetal size, sex and placental angiogenesis in the pig.Biology of reproduction · 2019Article
- Exposure to maternal obesity alters gene expression in the preimplantation ovine conceptus.BMC genomics · 2018Article
- A high resolution atlas of gene expression in the domestic sheep (Ovis aries).PLoS genetics · 2017Article
- Sexual Dimorphism of miRNAs Secreted by BovineFrontiers in genetics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cattle, maternal recognition of pregnancy occurs on Day 16 via secretion of interferon tau (IFNT) by the conceptus. The endometrium can distinguish between embryos with different developmental competencies. In eutherian mammals, X-chromosome inactivation (XCI) is required to ensure an equal transcriptional level of most X-linked genes for both male and female embryos in adult tissues, but this process is markedly different in cattle than mice. We examined how sexual dimorphism affected conceptus transcript abundance and amino acid composition as well as the endometrial transcriptome during the peri-implantation period of pregnancy. Of the 5132 genes that were differentially expressed on Day 19 in male compared to female conceptuses, 2.7% were located on the X chromosome. Concentrations of specific amino acids were higher in the uterine luminal fluid of male compared to female conceptuses, while female conceptuses had higher transcript abundance of specific amino acid transporters (SLC6A19 and SLC1A35). Of note, the endometrial transcriptome was not different in cattle gestating a male or a female conceptus. These data support the hypothesis that, far from being a blastocyst-specific phenomenon, XCI is incomplete before and during implantation in cattle. Despite differences in transcript abundance and amino acid utilization in male versus female conceptuses, the sex of the conceptus itself does not elicit a different transcriptomic response in the endometrium.
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Registered trials
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