Trial reportScientific reports2016
The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Body mass index (BMI) and risk of lung cancer: a systematic review and meta-analysis of studies using directly measured and genetically proxied measures of BMI.Cancer causes & control : CCC · 2026Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- ISSLS Prize in Clinical Science 2020. Examining causal effects of body mass index on back pain: a Mendelian randomization study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020 · on this mapPooled it
- Adiposity and cancer at major anatomical sites: umbrella review of the literature.BMJ (Clinical research ed.) · 2017Pooled it
- Genetic evidence supporting obesity as a risk factor for lung squamous cell carcinoma and the identification of MFAP1 as a shared genetic target.Discover oncology · 2026Article
- Assessing genetic causal relationship between milk fat content and chronic kidney disease: a two-sample Mendelian randomization study.Renal failure · 2025Article
- High Circulating Platelet Count as a Risk Factor for Lung Squamous Cell Carcinoma: A Retrospective Study and Mendelian Randomization Analysis.The clinical respiratory journal · 2025Article
- Allometric fat mass index and alanine aminotransferase attenuate the associations of platelet parameters with lung cancer risk.Scientific reports · 2024Article
- Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study.European heart journal · 2024Article
- Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study.Journal of the Endocrine Society · 2023Article
- The Role of Mendelian Randomization Studies in Deciphering the Effect of Obesity on Cancer.Journal of the National Cancer Institute · 2022Article
- A modifiable risk factors atlas of lung cancer: A Mendelian randomization study.Cancer medicine · 2021Article
- Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization.International journal of cancer · 2021Article
- The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study.Human molecular genetics · 2019Article
- Waist circumference and risk of 23 site-specific cancers: a population-based cohort study of Korean adults.British journal of cancer · 2018Article
- Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Review
- Mendelian randomization studies of cancer risk: a literature review.Current epidemiology reports · 2018Article
- Fat but fit for the improved survival in lung cancer surgery.Journal of thoracic disease · 2018Article
- Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies.BMC cancer · 2018Article
- Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study.European journal of epidemiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 14 institutions in 5 countries.
Funding
Abstract
Body mass index (BMI) is inversely associated with lung cancer risk in observational studies, even though it increases the risk of several other cancers, which could indicate confounding by tobacco smoking or reverse causality. We used the two-sample Mendelian randomization (MR) approach to circumvent these limitations of observational epidemiology by constructing a genetic instrument for BMI, based on results from the GIANT consortium, which was evaluated in relation to lung cancer risk using GWAS results on 16,572 lung cancer cases and 21,480 controls. Results were stratified by histological subtype, smoking status and sex. An increase of one standard deviation (SD) in BMI (4.65 Kg/m(2)) raised the risk for lung cancer overall (OR = 1.13; P = 0.10). This was driven by associations with squamous cell (SQ) carcinoma (OR = 1.45; P = 1.2 × 10(-3)) and small cell (SC) carcinoma (OR = 1.81; P = 0.01). An inverse trend was seen for adenocarcinoma (AD) (OR = 0.82; P = 0.06). In stratified analyses, a 1 SD increase in BMI was inversely associated with overall lung cancer in never smokers (OR = 0.50; P = 0.02). These results indicate that higher BMI may increase the risk of certain types of lung cancer, in particular SQ and SC carcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.