ArticleMolecular systems biology2016
Negative frequency-dependent interactions can underlie phenotypic heterogeneity in a clonal microbial population.
Article in Molecular systems biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Stochastic phenotypic switching arises in response to directional selection in experimentally evolved multicellular yeast.Communications biology · 2025Article
- Quantitative systems-based prediction of antimicrobial resistance evolution.NPJ systems biology and applications · 2023Review
- Permissive aggregative group formation favors coexistence between cooperators and defectors in yeast.The ISME journal · 2022Article
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- New insights into phenotypic heterogeneity for the distinct lipid accumulation of Schizochytrium sp. H016.Biotechnology for biofuels and bioproducts · 2022Article
- Frequency-Dependent Competition Between Strains Imparts Persistence to Perturbations in a Model ofFrontiers in ecology and evolution · 2021Article
- Selection for rapid uptake of scarce or fluctuating resource explains vulnerability of glycolysis to imbalance.PLoS computational biology · 2021Article
- Strain Background, Species Frequency, and Environmental Conditions Are Important in Determining Pseudomonas aeruginosa and Staphylococcus aureus Population Dynamics and Species Coexistence.Applied and environmental microbiology · 2020Article
- Cooperation mitigates diversity loss in a spatially expanding microbial population.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Fixation probabilities for the Moran process in evolutionary games with two strategies: graph shapes and large population asymptotics.Journal of mathematical biology · 2019Article
- Modeling cell population dynamics.In silico biology · 2019Article
- Spatial coordination in a mutually beneficial bacterial community enhances its antibiotic resistance.Communications biology · 2019Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- A single mutation inCommunications biology · 2018Article
- Predicting metabolic adaptation from networks of mutational paths.Nature communications · 2017Article
- Negative frequency-dependent interactions can underlie phenotypic heterogeneity in a clonal microbial population.Molecular systems biology · 2016Article
- Frequency-dependent selection: a diversifying force in microbial populations.Molecular systems biology · 2016Article
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3 authors.
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Abstract
Genetically identical cells in microbial populations often exhibit a remarkable degree of phenotypic heterogeneity even in homogenous environments. Such heterogeneity is commonly thought to represent a bet-hedging strategy against environmental uncertainty. However, evolutionary game theory predicts that phenotypic heterogeneity may also be a response to negative frequency-dependent interactions that favor rare phenotypes over common ones. Here we provide experimental evidence for this alternative explanation in the context of the well-studied yeast GAL network. In an environment containing the two sugars glucose and galactose, the yeast GAL network displays stochastic bimodal activation. We show that in this mixed sugar environment, GAL-ON and GAL-OFF phenotypes can each invade the opposite phenotype when rare and that there exists a resulting stable mix of phenotypes. Consistent with theoretical predictions, the resulting stable mix of phenotypes is not necessarily optimal for population growth. We find that the wild-type mixed strategist GAL network can invade populations of both pure strategists while remaining uninvasible by either. Lastly, using laboratory evolution we show that this mixed resource environment can directly drive the de novo evolution of clonal phenotypic heterogeneity from a pure strategist population. Taken together, our results provide experimental evidence that negative frequency-dependent interactions can underlie the phenotypic heterogeneity found in clonal microbial populations.
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