ArticleThe Journal of general virology2016
Pathogenesis of Korean SapelovirusA in piglets and chicks.
Article in The Journal of general virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- The Emergence and Evolution of Porcine Sapelovirus: Insights from Genomic Surveillance and Recombination Analysis in China.Viruses · 2026Article
- Fecal metatranscriptomics and virus isolation reveal picornavirus diversity and evolution in Japanese wild boars and pigs.Scientific reports · 2026Article
- Seroprevalence, Genetic Characteristics, and Pathogenicity of Korean Porcine Sapeloviruses.Viruses · 2025Article
- First Isolation and Characterization of Three Strains of Porcine Sapelovirus in Yunnan Province, China.Viruses · 2025Article
- Development of an Indirect ELISA to Distinguish between Porcine Sapelovirus-Infected and -Vaccinated Animals Using the Viral Nonstructural Protein 3AB.Current issues in molecular biology · 2024Article
- High Prevalence, Genetic Diversity, and Recombination ofViruses · 2023Article
- Development of an indirect ELISA method based on the VP1 protein for detection of IgG antibodies against porcine sapelovirus.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Premature farrowing and stillbirths in two organic sow farms due to riboflavin deficiency.Porcine health management · 2023Article
- Isolation and Characterization of Porcine Sapelovirus from the PDCoV-Positive Sample and Its Molecular Epidemiology in Henan Province, China.Transboundary and emerging diseases · 2023Article
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- Porcine sapelovirus 2A protein induces mitochondrial-dependent apoptosis.Frontiers in immunology · 2022Article
- Porcine teschovirus, sapelovirus, and enterovirus in Swiss pigs: multiplex RT-PCR investigation of viral frequencies and disease association.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
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- Multiple Types of Novel Enteric Bopiviruses (Viruses · 2021Article
- High prevalence, genetic diversity and a potentially novel genotype of Sapelovirus A (The Journal of general virology · 2020Article
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- Dual Recognition of Sialic Acid and αGal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains.Journal of virology · 2019Article
- Complete genomic analysis and molecular characterization of Japanese porcine sapeloviruses.Virus genes · 2019Article
- First Identification and Genomic Characterization of a Porcine Sapelovirus from Corsica, France, 2017.Microbiology resource announcements · 2018Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
Abstract
Sapelovirus A (SV-A), formerly known as porcine sapelovirus as a member of a new genus Sapelovirus, is known to cause enteritis, pneumonia, polioencephalomyelitis and reproductive disorders in pigs. We have recently identified α2,3-linked sialic acid on GD1a ganglioside as a functional SV-A receptor rich in the cells of pigs and chickens. However, the role of GD1a in viral pathogenesis remains elusive. Here, we demonstrated that a Korean SV-A strain could induce diarrhoea and intestinal pathology in piglets but not in chicks. Moreover, this Korean SV-A strain had mild extra-intestinal tropisms appearing as mild, non-suppurative myelitis, encephalitis and pneumonia in piglets, but not in chicks. By real-time reverse transcription (RT) PCR, higher viral RNA levels were detected in faecal samples than in sera or extra-intestinal organs from virus-inoculated piglets. Immunohistochemistry confirmed that high viral antigens were detected in the epithelial cells of intestines from virus-inoculated piglets but not from chicks. This Korean SV-A strain could bind the cultured cell lines originated from various species, but replication occurred only in cells of porcine origin. These data indicated that this Korean SV-A strain could replicate and induce pathology in piglets but not in chicks, suggesting that additional porcine-specific factors are required for virus entry and replication. In addition, this Korean SV-A strain is enteropathogenic, but could spread to the bloodstream from the gut and disseminate to extra-intestinal organs and tissues. These results will contribute to our understanding of SV-A pathogenesis so that efficient anti-sapelovirus drugs and vaccines could be developed in the future.
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