ArticleeLife2016
Gating of reafference in the external cuneate nucleus during self-generated movements in wake but not sleep.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- Self-vocalizations activate the developing auditory cortex via an intracortical pathway.Science advances · 2026Article
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- A transient feature of the inferior olive supports the development of cerebellar internal models.bioRxiv : the preprint server for biology · 2025Article
- Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p.eLife · 2025Article
- More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Sleep as a driver of pre- and postnatal brain development.Pediatric research · 2024Review
- Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmentally unique cerebellar processing prioritizes self-over other-generated movements.bioRxiv : the preprint server for biology · 2024Article
- Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition.Cell reports · 2023Article
- Neuro-orchestration of sleep and wakefulness.Nature neuroscience · 2023Review
- The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion.eLife · 2022Article
- Review
- Stress Adaptation and the Brainstem with Focus on Corticotropin-Releasing Hormone.International journal of molecular sciences · 2021Review
- Review
- Sensory Coding of Limb Kinematics in Motor Cortex across a Key Developmental Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Parallel and Serial Sensory Processing in Developing Primary Somatosensory and Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Roles for Sleep in Neural and Behavioral Plasticity: Reviewing Variation in the Consequences of Sleep Loss.Frontiers in behavioral neuroscience · 2021Review
- The Cerebellar Nuclei and Dexterous Limb Movements.Neuroscience · 2020Review
- Spatiotemporal organization of myoclonic twitching in sleeping human infants.Developmental psychobiology · 2020Article
- Self-Generated Whisker Movements Drive State-Dependent Sensory Input to Developing Barrel Cortex.Current biology : CB · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nervous systems distinguish between self- and other-generated movements by monitoring discrepancies between planned and performed actions. To do so, corollary discharges are conveyed to sensory areas and gate expected reafference. Such gating is observed in neonatal rats during wake-related movements. In contrast, twitches, which are self-generated movements produced during active (or REM) sleep, differ from wake movements in that they reliably trigger robust neural activity. Accordingly, we hypothesized that the gating actions of corollary discharge are absent during twitching. Here, we identify the external cuneate nucleus (ECN), which processes sensory input from the forelimbs, as a site of movement-dependent sensory gating during wake. Whereas pharmacological disinhibition of the ECN unmasked wake-related reafference, twitch-related reafference was unaffected. This is the first demonstration of a neural comparator that is differentially engaged depending on the kind of movement produced. This mechanism explains how twitches, although self-generated, trigger abundant reafferent activation of sensorimotor circuits in the developing brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.