Evidence map›Paper›PMID 27486964›Full record

ArticleAmerican journal of respiratory cell and molecular biology2016

Protein Kinase Cζ Inhibitor Promotes Resolution of Bleomycin-Induced Acute Lung Injury.

Luis G Vargas Buonfiglio, Mosaab Bagegni, Jennifer A Borcherding, Jessica C Sieren, Juan C Caraballo, Andrew Reger, Joseph Zabner, Xiaopeng Li, Alejandro P Comellas

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Luis G Vargas Buonfiglio1 Internal Medicine Department, Division of Pulmonary, Critical Care, and Occupational Medicine, and.
Mosaab Bagegni1 Internal Medicine Department, Division of Pulmonary, Critical Care, and Occupational Medicine, and.
Jennifer A Borcherding1 Internal Medicine Department, Division of Pulmonary, Critical Care, and Occupational Medicine, and.
Jessica C Sieren2 Radiology Department, University of Iowa, Iowa City, Iowa.
Juan C Caraballo1 Internal Medicine Department, Division of Pulmonary, Critical Care, and Occupational Medicine, and.
Andrew Reger1 Internal Medicine Department, Division of Pulmonary, Critical Care, and Occupational Medicine, and.
Joseph Zabner1 Internal Medicine Department, Division of Pulmonary, Critical Care, and Occupational Medicine, and.
Xiaopeng Li1 Internal Medicine Department, Division of Pulmonary, Critical Care, and Occupational Medicine, and.
Alejandro P Comellas1 Internal Medicine Department, Division of Pulmonary, Critical Care, and Occupational Medicine, and.
Institute of Occupational Medicine · SGUniversity of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
NCRR NIH HHS UL1 RR024979NHLBI NIH HHS P01 HL091842NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Protein kinase Cζ (PKCζ) is highly expressed in the lung, where it plays several regulating roles in the pathogenesis of acute lung injury (ALI). Proliferation and differentiation of integrin β4

Indexed as

Acute Lung InjuryAnimalsBleomycinBronchoalveolar Lavage FluidCell DeathCell MovementCell ProliferationCell SeparationComplianceDisease Models, AnimalEnzyme ActivationEpithelial CellsMice, Inbred C57BLModels, BiologicalNeutrophilsPermeabilityBleomycinProtein Kinase CProtein Kinase C zetaProtein Kinase InhibitorsReactive Oxygen SpeciesTransforming Growth Factor betaadult stem cellsintegrin-β4lung compliancelung fibrosisrespiratory distress syndrome

Identifiers

PMID27486964
PMCPMC5248948
OpenAlexW2497879590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.