Evidence map›Paper›PMID 27486849›Full record

ReviewBiopolymers2016

Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors.

Victor J Hruby

Open access · greenAbstract readReview
In one paragraph

Review in Biopolymers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Victor J HrubyDepartment of Chemistry and Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, Arizona, 85721, USA.
University of Arizona · US

Funding

PEPTIDE HORMONE STRUCTURE &FUNCTIONR01DK017420 · NIDDK · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 1986 to 2010
$2.8M
Supplement for "Designing Novel Melanotropins for New Applications for the Melanocortin System"R01GM108040 · NIGMS · UNIVERSITY OF ARIZONA · PI CAI, MINYING, HRUBY, VICTOR J · 2014 to 2017
$1.2M
NIDDK NIH HHS R01 DK017420NIGMS NIH HHS R01 GM108040
6 · The paper itself

Abstract

Design of biologically active peptides is of critical importance for the development of potent, selective, nontoxic bioavailable drugs. A major approach that has been developed to accomplish this is the development of methods for the design and synthesis of a wide variety of cyclic peptides and peptidomimetics. In this short and general review, we outline the methods that have been developed for cyclization of peptides and how these have been used for peptide and peptidomimetic design using the melanotropin peptides and melanocortin receptors MC1R, MC3R, MC4R, and MC5R to illustrate aspects of this approach.

Indexed as

Peptides, CyclicPeptidomimeticsAnimalsHumansReceptors, MelanocortinPeptides, CyclicPeptidomimeticsReceptors, Melanocortinconformational constraintscyclic peptidespeptide design

Identifiers

PMID27486849
PMCPMC5120999
OpenAlexW2482320606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.