ArticleGerontology2017
Pain Intensity and Pain Interference in Older Adults: Role of Gender, Obesity and High-Sensitivity C-Reactive Protein.
Article in Gerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Association Between Sedentary Behavior and the Development of New-Onset Chronic Pain in Older American Adults: Insights From the Health and Retirement Study.American journal of health promotion : AJHP · 2026Article
- Systemic inflammation mediating the relationship between lifestyle factors and musculoskeletal pain: a systematic review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- A prospective cohort study on perioperative percutaneous balloon compression for trigeminal neuralgia: safety and efficacy analysis.Neurosurgical review · 2024Article
- Circulating Inflammatory Biomarkers Predict Pain Change Following Exercise-Induced Shoulder Injury: Findings From the Biopsychosocial Influence on Shoulder Pain Preclinical Trial.The journal of pain · 2023Article
- Polygenic Contributions to Chronic Overlapping Pain Conditions in a Large Electronic Health Record Sample.The journal of pain · 2023Article
- Individuals with both higher recent negative affect and physical pain have higher levels of C-reactive protein.Brain, behavior, & immunity - health · 2022Article
- Relationship between fatty acid intake and chronic neck/shoulder/upper limb pain without elevated CRP in a Japanese population: a cross-sectional analysis of the Shika study.Journal of nutritional science · 2022Article
- The effect of obesity on pain severity and pain interference.Pain management · 2021Article
- Life Stressors: Elevations and Disparities Among Older Adults with Pain.Pain medicine (Malden, Mass.) · 2020Article
- Frailty modifies the intervention effect of chair yoga on pain among older adults with lower extremity osteoarthritis: Secondary analysis of a nonpharmacological intervention trial.Experimental gerontology · 2020Article
- The Association of Beta-Blocker Use to Cognitive Impairment among Adults with Hypertension or Cardiovascular Diseases in the United States.Chronic pain & management · 2020Article
- Association of osteoarthritis and pain with Alzheimer's Diseases and Related Dementias among older adults in the United States.Osteoarthritis and cartilage · 2019Article
- Article
- Prevalence of pain and its associated factors among the oldest-olds in different care settings - results of the AgeQualiDe study.BMC family practice · 2018Article
- High fat diet sensitizes fibromyalgia-like pain behaviors in mice via tumor necrosis factor alpha.PloS one · 2018Article
- Validity of the Korean Version of the Face, Legs, Activity, Cry, and Consolability Scale for Assessment of Pain in Dementia Patients.Journal of Korean medical science · 2017Article
- Observational
- The Strong Correlation Between Pain Interference and Abnormal Nutritional Status in Older Adults With Chronic Musculoskeletal Pain.Journal of primary care & community healthArticle
- Risk Factors for Pain in Autosomal Dominant Polycystic Kidney Disease: A New Research Trajectory.Kidney medicineArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAmong older adults, pain intensity and pain interference are more common in women than men and associated with obesity and inflammatory markers.
objectiveWe examined whether the obesity and pain relationship is mediated by the high-sensitivity C-reactive protein (hsCRP), a nonspecific marker of systemic inflammation, and whether this relationship differs by sex.
methodsItems from Medical Outcomes Study Short Form-36 were used to measure pain intensity and pain interference in daily life. Ordinal logistic regression was used to assess the cross-sectional association among body mass index (BMI), hsCRP levels, pain intensity and pain interference using gender-stratified models adjusted for demographic variables.
resultsParticipants included 667 community-residing adults over the age of 70 years, free of dementia, enrolled in the Einstein Aging Study (EAS). In women (n = 410), pain intensity was associated with obesity [BMI ≥30 vs. normal, odds ratio (OR) = 2.29, 95% confidence interval (CI) 1.43-3.68] and higher hsCRP (OR = 1.28, 95% CI 1.08-1.51). In a model with obesity and hsCRP, both remained significant, but the association between hsCRP and pain intensity was somewhat attenuated. Obesity (OR = 3.04, 95% CI 1.81-5.11) and higher hsCRP levels (OR = 1.30, 95% CI 1.08-1.56) were also independently associated with greater pain interference in women. After adjustment for pain intensity and BMI, hsCRP was no longer associated with pain interference in women. Greater pain intensity and being overweight or obese continued to be significantly associated with pain interference in women. In men (n = 257), obesity and hsCRP were not associated with pain intensity or pain interference.
conclusionsIn women, the relationship between obesity and higher levels of pain intensity or interference may be accounted for by factors related to hsCRP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.