Trial reportPLoS neglected tropical diseases2016
Molecular Identification of Hookworm Isolates in Humans, Dogs and Soil in a Tribal Area in Tamil Nadu, India.
Trial report in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- Community-wide deworming strategies to reduce high hookworm burden in endemic communities: Results from a cluster randomized trial in Southern India.PLoS neglected tropical diseases · 2026Trial
- Investigations into the association between soil-transmitted helminth infections, haemoglobin and child development indices in Manufahi District, Timor-Leste.Parasites & vectors · 2017Trial
- Molecular identification of zoonotic hookworms in environmentally collected canine fecal samples in Northern Philippines.Veterinary research communications · 2026Article
- Prevalence of Zoonotic Parasites and Genetic Diversity ofJournal of parasitology research · 2026Article
- The Canine HookwormPathogens (Basel, Switzerland) · 2025Article
- Hookworm infections in carnivores in Iran: a One Health concern.BMC veterinary research · 2025Article
- Identification of Ancylostoma caninum in Domestic Dogs from Ecuador via Various Techniques.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- The occurrence of cross-host species soil-transmitted helminth infections in humans and domestic/livestock animals: A systematic review.PLOS global public health · 2025Article
- Efficacy of Anthelmintics Against Canine Hookworm Infections in the Bono East Region of Ghana.Journal of parasitology research · 2025Article
- Soil surveillance for monitoring soil-transmitted helminths: Method development and field testing in three countries.PLoS neglected tropical diseases · 2024Article
- Anthroponotic and Zoonotic Hookworm DNA in an Indigenous Community in Coastal Ecuador: Potential Cross-Transmission between Dogs and Humans.Pathogens (Basel, Switzerland) · 2024Article
- Phytochemical analysis and anthelmintic activity of Combretum mucronatum leaf extract against infective larvae of soil-transmitted helminths including ruminant gastrointestinal nematodes.Parasites & vectors · 2024Article
- Immunity mediates host specificity in the human hookwormParasitology · 2024Article
- Epidemiological and molecular updates on hookworm species in dogs from southern Italy.BMC veterinary research · 2023Article
- Molecular evidence of hookworms in public environment of Bangladesh.Scientific reports · 2023Article
- Article
- First Molecular Identification of Ancylostoma Species in Dogs in a Rural Tea Estate Community in Sri Lanka and the Detection of Other Zoonotic Gastro-intestinal Parasites.Acta parasitologica · 2022Article
- Assessment of environmental contamination with soil-transmitted helminths life stages at school compounds, households and open markets in Jimma Town, Ethiopia.PLoS neglected tropical diseases · 2022Article
- Expression and biological functions of Ancylostoma ceylanicum saposin-like protein.Parasitology research · 2021Article
- A One Health Approach to Defining Animal and Human Helminth Exposure Risks in a Tribal Village in Southern India.The American journal of tropical medicine and hygiene · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundHookworms (Necator americanus and Ancylostoma duodenale) remain a major public health problem worldwide. Infections with hookworms (e.g., A. caninum, A. ceylanicum and A. braziliense) are also prevalent in dogs, but the role of dogs as a reservoir for zoonotic hookworm infections in humans needs to be further explored. METHODOLOGY/PRINCIPAL
findingsAs part of an open-label community based cluster-randomized trial in a tribal area in Tamil Nadu (India; 2013-2015), a total of 143 isolates of hookworm eggs from human stool were speciated based on a previously described PCR-RFLP methodology. The presence of hookworm DNA was confirmed in 119 of 143 human samples. N. americanus (100%) was the most prevalent species, followed by A. caninum (16.8%) and A. duodenale (8.4%). Because of the high prevalence of A. caninum in humans, dog samples were also collected to assess the prevalence of A. caninum in dogs. In 68 out of 77 canine stool samples the presence of hookworms was confirmed using PCR-RFLP. In dogs, both A. caninum (76.4%) and A. ceylanicum (27.9%) were identified. Additionally, to determine the contamination of soil with zoonotic hookworm larvae, topsoil was collected from defecating areas. Hookworm DNA was detected in 72 out of 78 soil samples that revealed presence of hookworm-like nematode larvae. In soil, different hookworm species were identified, with animal hookworms being more prevalent (A. ceylanicum: 60.2%, A. caninum: 29.4%, A. duodenale: 16.6%, N. americanus: 1.4%, A. braziliense: 1.4%). CONCLUSIONS/SIGNIFICANCE: In our study we regularly detected the presence of A. caninum DNA in the stool of humans. Whether this is the result of infection is currently unknown but it does warrant a closer look at dogs as a potential reservoir.
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Registered trials
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