ArticlePediatric research2016
Cerebrospinal fluid cytokines in the diagnosis of bacterial meningitis in infants.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Recent advances in diagnostic technologies for postoperative central nervous system infections: a review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
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- Clinical, Laboratory Characteristics, and Microorganism Infection Status in Neonates With Meningitis in Vietnam: A Cross-Sectional Descriptive Study.International journal of pediatrics · 2025Article
- The diagnostic and prognostic value of heparin-binding protein in cerebrospinal fluid for patients with intracranial infections.European journal of medical research · 2024Article
- An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice.The Journal of infectious diseases · 2024Article
- Granulocytes in cerebrospinal fluid of adults suspected of a central nervous system infection: a prospective study of diagnostic accuracy.Infection · 2024Article
- Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections.The Journal of infection · 2024Article
- The evaluation of antimicrobial stewardship for bacterial meningitis in neonates.Pediatric discovery · 2024Article
- Pro-inflammatory cerebrospinal fluid profile of neonates with intraventricular hemorrhage: clinical relevance and contrast with CNS infection.Fluids and barriers of the CNS · 2024Article
- Cerebrospinal fluid cytokines and chemokines exhibit distinct profiles in bacterial meningitis and viral meningitis.Experimental and therapeutic medicine · 2023Article
- Bacteria commonly associated with central nervous system catheter infections elicit distinct CSF proteome signatures.Frontiers in neurology · 2023Article
- Group B Streptococcal Neonatal Meningitis.Clinical microbiology reviews · 2022Review
- Deciphering the TLR transcriptome and downstream signaling pathway in cerebrospinal fluid in pediatric meningitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- High-throughput sequencing unravels the cell heterogeneity of cerebrospinal fluid in the bacterial meningitis of children.Frontiers in immunology · 2022Article
- Vimentin Regulates Chemokine Expression and NOD2 Activation in Brain Endothelium during Group B Streptococcal Infection.Infection and immunity · 2021Article
- Article
- Diagnostic value of heparin-binding protein in the cerebrospinal fluid for purulent meningitis in children.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- An improved clinical prediction rule for identifying neonatal bacterial meningitis: a multicenter cohort study.Translational pediatrics · 2021Article
- Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis.Journal of neuroinflammation · 2020Article
- Coagulase-negative staphylococci (CoNS) meningitis: a narrative review of the literature from 2000 to 2020.New microbes and new infections · 2020Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial meningitis poses diagnostic challenges in infants. Antibiotic pretreatment and low bacterial density diminish cerebrospinal fluid (CSF) culture yield, while laboratory parameters do not reliably identify bacterial meningitis. Pro and anti-inflammatory cytokines are elevated in bacterial meningitis and may be useful diagnostic adjuncts when CSF cultures are negative.
methodsIn a prospective cohort study of infants, we used cytometric bead arrays to measure tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), IL-6, IL-8, IL-10, and IL-12 in CSF. Receiver operating characteristic (ROC) analyses and Principal component analysis (PCA) were used to determine cytokine combinations that identified bacterial meningitis.
resultsSix hundred and eighty four infants < 6 mo were included; 11 had culture-proven bacterial meningitis. IL-6 and IL-10 were the individual cytokines possessing greatest accuracy in diagnosis of culture proven bacterial meningitis (ROC analyses; area under the concentration-time curve (AUC) 0.91; 0.9103 respectively), and performed as well as, or better than combinations identified using ROC and PCA. CSF cytokines were highly correlated with each other and with CSF white blood cell count (WBC) counts in infants with meningitis. A subset of antibiotic pretreated culture-negative subjects demonstrated cytokine patterns similar to culture positive subjects.
conclusionCSF cytokine levels may aid diagnosis of bacterial meningitis, and facilitate decision-making regarding treatment for culture negative meningitis.
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