ArticleBMJ open diabetes research & care2016
Peripheral sensory neuropathy is associated with altered postocclusive reactive hyperemia in the diabetic foot.
Article in BMJ open diabetes research & care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06219590 (Acetylcholine Iontophoresis As A New Challenge With Type 2 Diabetic Peripheral Neuropathy), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acetylcholine Iontophoresis As A New Challenge With Type 2 Diabetic Peripheral Neuropathy: A Possible New Therapy
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Reactive Hyperemia and Cardiovascular Autonomic Neuropathy in Type 2 Diabetic Patients: A Systematic Review of Randomized and Nonrandomized Clinical Trials.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Cutaneous microvascular reactivity in Charcot neuroarthropathy: a systematic review and meta-analysis.Journal of foot and ankle research · 2022Pooled it
- Autonomic cardiovascular changes during reactive hyperemia.Clinical physiology and functional imaging · 2026Article
- Pressure-Induced Microvascular Reactivity With Whole Foot Loading Is Unique Across the Human Foot Sole.Microcirculation (New York, N.Y. : 1994) · 2025Article
- An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition.Biophysical reviews · 2024Review
- Mechanoreceptor sensory feedback is impaired by pressure induced cutaneous ischemia on the human foot sole and can predict cutaneous microvascular reactivity.Frontiers in neuroscience · 2024Article
- Multifactorial analysis of risk factors for foot ulcers in patients with neurovascular complications of diabetes.Frontiers in endocrinology · 2024Article
- Functional near infrared spectroscopy detects cortical activation changes concurrent with memory loss in postmenopausal women with Type II Diabetes.Experimental brain research · 2023Article
- Stem Cell-Based Therapy for Diabetic Foot Ulcers.Frontiers in cell and developmental biology · 2022Review
- The Role of Cutaneous Microcirculatory Responses in Tissue Injury, Inflammation and Repair at the Foot in Diabetes.Frontiers in bioengineering and biotechnology · 2021Review
- Functional neuroimaging of sensorimotor cortices in postmenopausal women with type II diabetes.Neurophotonics · 2020Article
- A Synoptic Overview of Neurovascular Interactions in the Foot.Frontiers in endocrinology · 2020Review
- Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging.Aging and disease · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study examined whether the presence of peripheral sensory neuropathy or cardiac autonomic deficits is associated with postocclusive reactive hyperemia (reflective of microvascular function) in the diabetic foot. RESEARCH DESIGN AND
methods99 participants with type 2 diabetes were recruited into this cross-sectional study. The presence of peripheral sensory neuropathy was determined with standard clinical tests and cardiac autonomic function was assessed with heart rate variation testing. Postocclusive reactive hyperemia was measured with laser Doppler in the hallux. Multiple hierarchical regression was performed to examine relationships between neuropathy and the peak perfusion following occlusion and the time to reach this peak.
resultsPeripheral sensory neuropathy predicted 22% of the variance in time to peak following occlusion (p<0.05), being associated with a slower time to peak but was not associated with the magnitude of the peak. Heart rate variation was not associated with the postocclusive reactive hyperemia response.
conclusionsThis study found an association between the presence of peripheral sensory neuropathy in people with diabetes and altered microvascular reactivity in the lower limb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.