ArticleFrontiers in microbiology2016
Factors Determining Staphylococcus aureus Susceptibility to Photoantimicrobial Chemotherapy: RsbU Activity, Staphyloxanthin Level, and Membrane Fluidity.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Antivirulence activities of Rutin-loaded chitosan nanoparticles against pathogenic Staphylococcus aureus.BMC microbiology · 2024Article
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- Prevalence of the SigB-Deficient Phenotype among ClinicalAntibiotics (Basel, Switzerland) · 2023Article
- Porphyrin Photosensitizers Grafted in Cellulose Supports: A Review.International journal of molecular sciences · 2023Review
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- Novel silver metformin nano-structure to impede virulence of Staphylococcus aureus.AMB Express · 2022Article
- Antibiofilm and staphyloxanthin inhibitory potential of terbinafine against Staphylococcus aureus: in vitro and in vivo studies.Annals of clinical microbiology and antimicrobials · 2022Article
- Celastrol mitigates staphyloxanthin biosynthesis and biofilm formation in Staphylococcus aureus via targeting key regulators of virulence; in vitro and in vivo approach.BMC microbiology · 2022Article
- Potentiated antimicrobial blue light killing of methicillin resistant Staphylococcus aureus by pyocyanin.Journal of photochemistry and photobiology. B, Biology · 2021Article
- Factors Determining the Susceptibility of Bacteria to Antibacterial Photodynamic Inactivation.Frontiers in medicine · 2021Review
- Validation of stable reference genes in Staphylococcus aureus to study gene expression under photodynamic treatment: a case study of SEB virulence factor analysis.Scientific reports · 2020Article
- Carotenoids are used as regulators for membrane fluidity by Staphylococcus xylosus.Scientific reports · 2020Article
- Within-host evolution of bovine Staphylococcus aureus selects for a SigB-deficient pathotype characterized by reduced virulence but enhanced proteolytic activity and biofilm formation.Scientific reports · 2019Article
- Development of Staphylococcus aureus tolerance to antimicrobial photodynamic inactivation and antimicrobial blue light upon sub-lethal treatment.Scientific reports · 2019Article
- Role of SigB and Staphyloxanthin in Radiation Survival of Staphylococcus aureus.Current microbiology · 2019Article
- Antimicrobials Are a Photodynamic Inactivation Adjuvant for the Eradication of Extensively Drug-ResistantFrontiers in microbiology · 2019Article
- Impact of Deficiencies in Branched-Chain Fatty Acids and Staphyloxanthin inBioMed research international · 2019Article
- Interrelationships between Fatty Acid Composition, Staphyloxanthin Content, Fluidity, and Carbon Flow in theMolecules (Basel, Switzerland) · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoantimicrobial chemotherapy (PACT) constitutes a particular type of stress condition, in which bacterial cells induce a pleiotropic and as yet unexplored effect. In light of this, the key master regulators are of putative significance to the overall phototoxic outcome. In Staphylococcus aureus, the alternative sigma factor σ(B) controls the expression of genes involved in the response to environmental stress. We show that aberration of any sigB operon genes in S. aureus USA300 isogenic mutants causes a pronounced sensitization (>5 log10 reduction in CFU drop) to PACT with selected photosensitizers, namely protoporphyrin diarginate, zinc phthalocyanine and rose bengal. This effect is partly due to aberration-coupled staphyloxanthin synthesis inhibition. We identified frequent mutations in RsbU, a σ(B) activator, in PACT-vulnerable clinical isolates of S. aureus, resulting in σ(B) activity impairment. Locations of significant changes in protein structure (IS256 insertion, early STOP codon occurrence, substitutions A230T and A276D) were shown in a theoretical model of S. aureus RsbU. As a phenotypic hallmark of PACT-vulnerable S. aureus strains, we observed an increased fluidity of bacterial cell membrane, which is a result of staphyloxanthin content and other yet unidentified factors. Our research indicates σ(B) as a promising target of adjunctive antimicrobial therapy and suggests that enhanced cell membrane fluidity may be an adjuvant strategy in PACT.
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