ArticleFrontiers in human neuroscience2016
Oxytocin and Social Sensitivity: Gene Polymorphisms in Relation to Depressive Symptoms and Suicidal Ideation.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Role of social cognition in post-traumatic stress disorder: A review and meta-analysis.Genes, brain, and behavior · 2019Pooled it
- Explaining the Link Between PTSD and Suicide: A Meta-Analysis to Introduce the CEASE Framework.Psychological reports · 2026Article
- CD38 genetic variation is associated with increased personal distress to an emotional stimulus.Scientific reports · 2024Article
- Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023Review
- Transdiagnostic biomarker approaches to mental health disorders: Consideration of symptom complexity, comorbidity and context.Brain, behavior, & immunity - health · 2021Article
- CD38 is associated with bonding-relevant cognitions and relationship satisfaction over the first 3 years of marriage.Scientific reports · 2021Observational
- Oxytocin Pathway Gene (Frontiers in psychiatry · 2021Article
- Oxytocin Receptor Gene Polymorphisms and Early Parental Bonding Interact in Shaping Instagram Social Behavior.International journal of environmental research and public health · 2020Article
- Candidate Biomarkers of Suicide Crisis Syndrome: What to Test Next? A Concept Paper.The international journal of neuropsychopharmacology · 2020Review
- Unextracted plasma oxytocin levels decrease following in-laboratory social exclusion in young adults with a suicide attempt history.Journal of psychiatric research · 2020Article
- A role for theThe American journal of drug and alcohol abuse · 2020Article
- Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.Frontiers in neuroscience · 2020Article
- Review
- Infancy onset maltreatment and the development of suicide ideation: An investigation of moderation by oxytocin-related gene polymorphisms.Journal of affective disorders · 2019Article
- Childhood adversity and parenting behavior: the role of oxytocin receptor gene polymorphisms.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth.Journal of affective disorders · 2019Article
- Neurobiological Aspects of Face Recognition: The Role of Oxytocin.Frontiers in behavioral neuroscience · 2018Review
- Direct Involvement of Androgen Receptor in Oxytocin Gene Expression: Possible Relevance for Mood Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors.Nutrition & diabetes · 2017Article
- Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities.Chronic stress (Thousand Oaks, Calif.) · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the neuropeptide oxytocin has been associated with enhanced prosocial behaviors, it has also been linked to aggression and mental health disorders. Thus, it was suggested that oxytocin might act by increasing the salience of social stimuli, irrespective of whether these are positive or negative, thus increasing vulnerability to negative mental health outcomes. The current study (N = 243), conducted among white university students, examined the relation of trauma, depressive symptoms including suicidal ideation in relation to a single nucleotide polymorphism (SNP) within the oxytocin receptor gene (OXTR), rs53576, and a SNP on the CD38 gene that controls oxytocin release, rs3796863. Individuals with the polymorphism on both alleles (AA genotype) of the CD38 SNP had previously been linked to elevated plasma oxytocin levels. Consistent with the social sensitivity perspective, however, in the current study, individuals carrying the AA genotype displayed elevated feelings of alienation from parents and peers as well as increased levels of suicidal ideation. Moreover, they tended to report elevated depressive symptoms compared to CC homozygotes. It was also observed that the CD38 genotype moderated the relation between trauma and suicidal ideation scores, such that high levels of trauma were associated with elevated suicidal ideation among all CD38 genotypes, but this relationship was stronger among individuals with the AA genotype. In contrast, there was no relationship between the OXTR SNP, rs53576, depression or suicidal ideation. These findings support a social sensitivity hypothesis of oxytocin, wherein the AA genotype of the CD38 SNP, which has been considered the "protective allele" was associated with increased sensitivity and susceptibility to disturbed social relations and suicidal ideation.
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