Evidence map›Paper›PMID 27486386›Full record

ArticleFrontiers in neuroscience2016

Manual-Protocol Inspired Technique for Improving Automated MR Image Segmentation during Label Fusion.

Nikhil Bhagwat, Jon Pipitone, Julie L Winterburn, Ting Guo, Emma G Duerden, Aristotle N Voineskos, Martin Lepage, Steven P Miller, Jens C Pruessner, M Mallar Chakravarty

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nikhil BhagwatInstitute of Biomaterials and Biomedical Engineering, University of TorontoToronto, ON, Canada; Cerebral Imaging Centre, Douglas Mental Health University InstituteVerdun, QC, Canada; Kimel Family Translational Imaging-Genetics Research Lab, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthToronto, ON, Canada.
Jon PipitoneKimel Family Translational Imaging-Genetics Research Lab, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Toronto, ON, Canada.
Julie L WinterburnInstitute of Biomaterials and Biomedical Engineering, University of TorontoToronto, ON, Canada; Cerebral Imaging Centre, Douglas Mental Health University InstituteVerdun, QC, Canada; Kimel Family Translational Imaging-Genetics Research Lab, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthToronto, ON, Canada.
Ting GuoNeurosciences and Mental Health, The Hospital for Sick Children Research InstituteToronto, ON, Canada; Department of Paediatrics, The Hospital for Sick Children and the University of TorontoToronto, ON, Canada.
Emma G DuerdenNeurosciences and Mental Health, The Hospital for Sick Children Research InstituteToronto, ON, Canada; Department of Paediatrics, The Hospital for Sick Children and the University of TorontoToronto, ON, Canada.
Aristotle N VoineskosKimel Family Translational Imaging-Genetics Research Lab, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthToronto, ON, Canada; Department of Psychiatry, University of TorontoToronto, ON, Canada.
Martin LepageCerebral Imaging Centre, Douglas Mental Health University InstituteVerdun, QC, Canada; Department of Psychiatry, McGill UniversityMontreal, QC, Canada.
Steven P MillerNeurosciences and Mental Health, The Hospital for Sick Children Research InstituteToronto, ON, Canada; Department of Paediatrics, The Hospital for Sick Children and the University of TorontoToronto, ON, Canada.
Jens C PruessnerCerebral Imaging Centre, Douglas Mental Health University InstituteVerdun, QC, Canada; McGill Centre for Studies in AgingMontreal, QC, Canada.
M Mallar ChakravartyInstitute of Biomaterials and Biomedical Engineering, University of TorontoToronto, ON, Canada; Cerebral Imaging Centre, Douglas Mental Health University InstituteVerdun, QC, Canada; Department of Psychiatry, McGill UniversityMontreal, QC, Canada; Biological and Biomedical Engineering, McGill UniversityMontreal, QC, Canada.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
1/3 - Social Processes Initiative in Neurobiology of the Schizophrenia(s)R01MH102324 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI VOINESKOS, ARISTOTLE NICHOLAS · 2014 to 2018
$1.4M
Effects of Maintenance Treatment with Olanzapine vs. Placebo on Brain StructureR01MH099167 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI VOINESKOS, ARISTOTLE NICHOLAS · 2013 to 2017
$1.4M
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"K01AG030514 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARMICHAEL, OWEN T. · 2008 to 2012
$495k
NIA NIH HHS K01 AG030514NIA NIH HHS P30 AG010129NIA NIH HHS U01 AG024904NIMH NIH HHS R01 MH099167NIMH NIH HHS R01 MH102324
6 · The paper itself

Abstract

Recent advances in multi-atlas based algorithms address many of the previous limitations in model-based and probabilistic segmentation methods. However, at the label fusion stage, a majority of algorithms focus primarily on optimizing weight-maps associated with the atlas library based on a theoretical objective function that approximates the segmentation error. In contrast, we propose a novel method-Autocorrecting Walks over Localized Markov Random Fields (AWoL-MRF)-that aims at mimicking the sequential process of manual segmentation, which is the gold-standard for virtually all the segmentation methods. AWoL-MRF begins with a set of candidate labels generated by a multi-atlas segmentation pipeline as an initial label distribution and refines low confidence regions based on a localized Markov random field (L-MRF) model using a novel sequential inference process (walks). We show that AWoL-MRF produces state-of-the-art results with superior accuracy and robustness with a small atlas library compared to existing methods. We validate the proposed approach by performing hippocampal segmentations on three independent datasets: (1) Alzheimer's Disease Neuroimaging Database (ADNI); (2) First Episode Psychosis patient cohort; and (3) A cohort of preterm neonates scanned early in life and at term-equivalent age. We assess the improvement in the performance qualitatively as well as quantitatively by comparing AWoL-MRF with majority vote, STAPLE, and Joint Label Fusion methods. AWoL-MRF reaches a maximum accuracy of 0.881 (dataset 1), 0.897 (dataset 2), and 0.807 (dataset 3) based on Dice similarity coefficient metric, offering significant performance improvements with a smaller atlas library (< 10) over compared methods. We also evaluate the diagnostic utility of AWoL-MRF by analyzing the volume differences per disease category in the ADNI1: Complete Screening dataset. We have made the source code for AWoL-MRF public at: https://github.com/CobraLab/AWoL-MRF.

Indexed as

Alzheimer's diseasefirst-episode-psychosishippocampusMR Imagingmulti-atlas label fusionpremature birth and neonatessegmentation

Identifiers

PMID27486386
PMCPMC4949270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.