ArticleInterdisciplinary toxicology2015
Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement.
Article in Interdisciplinary toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- The Beneficial Effect of Ononis natrix Against Pb-Induced Sensorimotor, Neurobehavioral, and Oxidative Stress Impairments in Mice Offspring during Gestation and Lactation.Biological trace element research · 2026Article
- Environmental lead risk in the 21st century.Communications earth & environment · 2025Review
- Cerebral Vascular Toxicity after Developmental Exposure to Arsenic (As) and Lead (Pb) Mixtures.Toxics · 2024Article
- No association between prenatal lead exposure and neurodevelopment during early childhood in the Japan Environment and Children's Study.Scientific reports · 2022Article
- Mechanisms associated with the dysregulation of mitochondrial function due to lead exposure and possible implications on the development of Alzheimer's disease.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Review
- Evaluation of Analytes Characterized with Potential Protective Action after Rat Exposure to Lead.Molecules (Basel, Switzerland) · 2021Article
- Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment.Frontiers in toxicology · 2021Review
- Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women.The Journal of nutrition · 2019Article
- Sex-Dependent Impact of Low-Level Lead Exposure during Prenatal Period on Child Psychomotor Functions.International journal of environmental research and public health · 2018Article
- Continuous Exposure to Inorganic Mercury Affects Neurobehavioral and Physiological Parameters in Mice.Journal of molecular neuroscience : MN · 2018Article
- Association between heavy metal levels and acute ischemic stroke.Journal of biomedical science · 2018Article
- Lead Affects Vitamin D Metabolism in Rats.Nutrients · 2018Article
- Effects of low-level prenatal lead exposure on child IQ at 4 and 8 years in a UK birth cohort study.Neurotoxicology · 2017Article
- Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our earlier studies showed that lactational exposure to lead (Pb) caused irreversible neurochemical alterations in rats. The present study was carried out to examine whether gestational exposure to Pb can cause long-term changes in the brain cholinergic system and behavior of rats. The protective effect of calcium (Ca) supplementation against Pb toxicity was also examined. Pregnant rats were exposed to 0.2% Pb (Pb acetate in drinking water) from gestational day (GD) 6 to GD 21. The results showed decrease in body weight gain (GD 6-21) of dams, whereas no changes were observed in offspring body weight at different postnatal days following Pb exposure. Male offspring treated with Pb showed marginal alterations in developmental landmarks such as unfolding of pinnae, lower and upper incisor eruption, fur development, eye slit formation and eye opening on postnatal day (PND) 1, whereas significant alterations were found in the righting reflex (PNDs 4-7), slant board behavior (PNDs 8-10) and forelimb hang performance (PNDs 12-16). Biochemical analysis showed decrease in synaptosomal acetylcholinesterase (AChE) activity and an increase in acetylcholine (ACh) levels in the cortex, cerebellum and hippocampus on PND 14, PND 21, PND 28 and in the four-month age group of rats following Pb exposure. Significant deficits were also observed in total locomotor activity, exploratory behavior and open field behavior in selected age groups of Pb-exposed rats. These alterations were found to be maximal on PND 28, corresponding with the greater blood lead levels observed on PND 28. Addition of 0.02% Ca to Pb reversed the Pb-induced impairments in the cholinergic system as well as in behavioral parameters of rats. In conclusion, these data suggest that gestational exposure to Pb is able to induce long-term changes in neurological functions of offspring. Maternal Ca administration reversed these neurological effects of Pb later in life, suggesting a protective effect of calcium in Pb-exposed animals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.