ArticlePoultry science2017
ALV-J strain SCAU-HN06 induces innate immune responses in chicken primary monocyte-derived macrophages.
Article in Poultry science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Isolation and identification of a highly oncogenic subgroup J avian leukosis virus strain from Chinese black chickens.Poultry science · 2026Article
- Autophagy-mediated TET2 degradation by ALV-J Env protein suppresses innate immune activation to promote viral replication.Journal of virology · 2025Article
- Dissection of key factors correlating with H5N1 avian influenza virus driven inflammatory lung injury of chicken identified by single-cell analysis.PLoS pathogens · 2023Article
- Avian Leukosis: Will We Be Able to Get Rid of It?Animals : an open access journal from MDPI · 2023Review
- Activation of lnc-ALVE1-AS1 inhibited ALV-J replication through triggering the TLR3 pathway in chicken macrophage like cell line.Veterinary research communications · 2023Article
- Comparative functional analysis of macrophage phagocytosis in Dagu chickens and Wenchang chickens.Frontiers in immunology · 2023Article
- Advances on genetic and genomic studies of ALV resistance.Journal of animal science and biotechnology · 2022Review
- Transcriptome Analyses of Chicken Primary Macrophages Infected With AttenuatedFrontiers in microbiology · 2022Article
- Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication.Frontiers in immunology · 2022Review
- Enhanced pathogenicity by up-regulation of A20 after avian leukemia subgroup a virus infection.Frontiers in veterinary science · 2022Article
- High-frequency and activation of CD4Veterinary research · 2021Article
- ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway.Frontiers in immunology · 2021Article
- Article
- A balanced game: chicken macrophage response to ALV-J infection.Veterinary research · 2019Article
- Molecular cloning and transcriptional regulation of Indian peafowl (Pavo cristatus) IFN-α gene.Cell stress & chaperones · 2019Article
- Macrophage Migration Inhibitory Factor Triggers Inflammatory Responses During Very Virulent Infectious Bursal Disease Virus Infection.Frontiers in microbiology · 2019Article
- Oxidative Stress in Poultry: Lessons from the Viral Infections.Oxidative medicine and cellular longevity · 2018Review
- Avian Leukosis Virus Subgroup J Attenuates Type I Interferon Production Through Blocking IκB Phosphorylation.Frontiers in microbiology · 2018Article
- ALV-J infection induces chicken monocyte death accompanied with the production of IL-1β and IL-18.Oncotarget · 2017Article
- Immunity to Avian Leukosis Virus: Where Are We Now and What Should We Do?Frontiers in immunology · 2016Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avian leucosis virus subgroup J (ALV-J) can cause lifelong infection and can escape from the host immune defenses in chickens. Since macrophages act as the important defense line against invading pathogens in host innate immunity, we investigated the function and innate immune responses of chicken primary monocyte-derived macrophages (MDM) after ALV-J infection in this study. Our results indicated that ALV-J was stably maintained in MDM cells but that the viral growth rate was significantly lower than that in DF-1 cells. We also found that ALV-J infection significantly increased nitric oxide (NO) production, but had no effect on MDM phagocytic capacity. Interestingly, infection with ALV-J rapidly promoted the expression levels of Myxovirus resistance 1 (Mx) (3 h, 6 h), ISG12 (6 h), and interleukin-1β (IL-1β) (3 h, 12 h) at an early infection stage, whereas it sharply decreased the expression of Mx (24 h, 36 h), ISG12 (36 h), and made little change on IL-1β (24 h, 36 h) production at a late infection stage in MDM cells. Moreover, the protein levels of interferon-β (IFN-β) and interleukin-6 (IL-6) had sharply increased in infected MDM cells from 3 to 36 h post infection (hpi) of ALV-J. And, the protein level of interleukin-10 (IL-10) was dramatically decreased at 36 hpi in MDM cells infected with ALV-J. These results demonstrate that ALV-J can induce host innate immune responses and we hypothesize that macrophages play an important role in host innate immune attack and ALV-J immune escape.
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