ReviewExperimental biology and medicine (Maywood, N.J.)2016
Biochemistry, function, and deficiency of vitamin B12 in Caenorhabditis elegans.
Review in Experimental biology and medicine (Maywood, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- A simple, fast and inexpensive approach using E. coli to detect and estimate vitamin B12 content in microbial extracts.Biology open · 2025Article
- Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling.Nature communications · 2025Article
- An improved medium for in vitro studies of female reproduction and oviposition in Schistosoma japonicum.Parasites & vectors · 2024Article
- Mediator subunit MDT-15 promotes expression of propionic acid breakdown genes to prevent embryonic lethality in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents.BMC biology · 2022Article
- Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span.Aging cell · 2022Article
- Lysosomal activity regulatesProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans.Genes & nutrition · 2020Review
- Betaine-rich sugar beet molasses protects from homocysteine-induced reduction of survival in Caenorhabditis elegans.European journal of nutrition · 2020Article
- Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity.Frontiers in nutrition · 2019Review
- Betaine reduces β-amyloid-induced paralysis through activation of cystathionine-β-synthase in an Alzheimer model ofGenes & nutrition · 2018Article
- Bi-directional effects of vitamin BScientific reports · 2017Article
- Coenzyme B12 synthesis as a baseline to study metabolite contribution of animal microbiota.Microbial biotechnology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caenorhabditis elegans is a nematode that has been widely used as an animal for investigation of diverse biological phenomena. Vitamin B12 is essential for the growth of this worm, which contains two cobalamin-dependent enzymes, methylmalonyl-CoA mutase and methionine synthase. A full complement of gene homologs encoding the enzymes associated with the mammalian intercellular metabolic processes of vitamin B12 is identified in the genome of C elegans However, this worm has no orthologs of the vitamin B12-binders that participate in human intestinal absorption and blood circulation. When the worm is treated with a vitamin B12-deficient diet for five generations (15 days), it readily develops vitamin B12 deficiency, which induces worm phenotypes (infertility, delayed growth, and shorter lifespan) that resemble the symptoms of mammalian vitamin B12 deficiency. Such phenotypes associated with vitamin B12 deficiency were readily induced in the worm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.