Evidence map›Paper›PMID 27486154›Full record

SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2016

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments.

Roumen V Milev, Peter Giacobbe, Sidney H Kennedy, Daniel M Blumberger, Zafiris J Daskalakis, Jonathan Downar, Mandana Modirrousta, Simon Patry, Fidel Vila-Rodriguez, Raymond W Lam and 4 more

2 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 223 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
223citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03761303 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

Investigation of the Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) as an add-on Therapy in Patients With Post-stroke Depression (PSD)

TypeinterventionalSponsorBDH-Klinik Hessisch OldendorfRan2018 to 2022Enrolled0ConditionsPost-stroke DepressionArmsactive rTMS, sham rTMS
NCT03977038 completednot on this mapstarted 2020, after this paper: background citation

Investigation of Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on "Hot" and "Cold" Cognitive Systems In Treatment Resistant Depression (TRD)

Typeobservational_patient_registrySponsorSunnybrook Health Sciences CentreRan2020 to 2022Enrolled25ConditionsMajor Depressive Disorder, Treatment Resistant DepressionArmsrepetitive transcranial magnetic stimulation
3 · Its place in the literature

Who cites it

223 citing papers in PubMed, 24 syntheses or guidelines pooled it.

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  8. Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis.Photobiomodulation, photomedicine, and laser surgery · 2023
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163 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Roumen V MilevDepartment of Psychiatry, Queen's University, Kingston, Ontario roumen.milev@queensu.ca.
Peter GiacobbeDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Sidney H KennedyDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Daniel M BlumbergerDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Zafiris J DaskalakisDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Jonathan DownarDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Mandana ModirroustaDepartment of Psychiatry, University of Manitoba, Winnipeg, Manitoba.
Simon PatryDepartment of Psychiatry, L'Université Laval, Québec City, Québec.
Fidel Vila-RodriguezDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
Raymond W LamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
Glenda M MacQueenDepartment of Psychiatry, University of Calgary, Calgary, Alberta.
Sagar V ParikhDepartment of Psychiatry, University of Toronto, Toronto, Ontario Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Arun V RavindranDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
CANMAT Depression Work Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals.

methodsUsing the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence. Recommendations for lines of treatment were based on the quality of evidence and clinical expert consensus. "Neurostimulation Treatments" is the fourth of six sections of the 2016 guidelines.

resultsEvidence-informed responses were developed for 31 questions for 6 neurostimulation modalities: 1) transcranial direct current stimulation (tDCS), 2) repetitive transcranial magnetic stimulation (rTMS), 3) electroconvulsive therapy (ECT), 4) magnetic seizure therapy (MST), 5) vagus nerve stimulation (VNS), and 6) deep brain stimulation (DBS). Most of the neurostimulation treatments have been investigated in patients with varying degrees of treatment resistance.

conclusionsThere is increasing evidence for efficacy, tolerability, and safety of neurostimulation treatments. rTMS is now a first-line recommendation for patients with MDD who have failed at least 1 antidepressant. ECT remains a second-line treatment for patients with treatment-resistant depression, although in some situations, it may be considered first line. Third-line recommendations include tDCS and VNS. MST and DBS are still considered investigational treatments.

Indexed as

CanadaDeep Brain StimulationElectroconvulsive TherapyEvidence-Based MedicineHumansMajor Depressive DisorderPractice Guidelines as TopicTranscranial Direct Current StimulationTranscranial Magnetic StimulationVagus Nerve Stimulationclinical practice guidelinesdeep brain stimulationelectroconvulsive therapyevidence-based medicinemajor depressive disordermeta-analysisneurostimulationrepetitive transcranial magnetic stimulationsystematic reviews

Identifiers

PMID27486154
PMCPMC4994792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.