Evidence map›Paper›PMID 27486153›Full record

SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2016

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 5. Complementary and Alternative Medicine Treatments.

Arun V Ravindran, Lynda G Balneaves, Guy Faulkner, Abigail Ortiz, Diane McIntosh, Rachel L Morehouse, Lakshmi Ravindran, Lakshmi N Yatham, Sidney H Kennedy, Raymond W Lam and 4 more

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 114 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 23 pooled it
58.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04037436 nacompletednot on this mapstarted 2019, after this paper: background citation

A Model for Delivering Strength Training and Nutrition Education for Older Adults (MoveStrong): A Pilot Randomized Controlled Trial

TypeinterventionalSponsorUniversity of WaterlooRan2019 to 2020Enrolled44ConditionsChronic Disease, Frail, Diabetes Mellitus, CancerArmsStrength and Balance Training & Nutrition Education, Usual Care
NCT06450704 narecruitingnot on this mapstarted 2025, after this paper: background citation

Inflammatory and Brain Mechanisms and Clinical and Cognitive Effects of an Exercise Intervention in Major Depressive Disorder: a Randomised Longitudinal Clinical Trial.

TypeinterventionalSponsorFundación de Investigación Biomédica - Hospital Universitario de La PrincesaRan2025 to 2026Enrolled124ConditionsMajor Depressive Disorder, Inflammatory ResponseArmsPhysical Exercise, Antidepressant medication (ADM)
3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 23 syntheses or guidelines pooled it, 325 citations in OpenAlex.

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  7. Nutraceuticals in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2024
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  8. The efficacy and safety of complementary and alternative medicine for depression: an umbrella review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2024
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  14. Guideline
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Arun V RavindranDepartment of Psychiatry, University of Toronto, Toronto, Ontario arun.ravindran@camh.ca.
Lynda G BalneavesDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Guy FaulknerSchool of Kinesiology, University of British Columbia, Vancouver, British Columbia.
Abigail OrtizDepartment of Psychiatry, University of Ottawa, Ottawa, Ontario.
Diane McIntoshDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
Rachel L MorehouseDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia.
Lakshmi RavindranDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Lakshmi N YathamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
Sidney H KennedyDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Raymond W LamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
Glenda M MacQueenDepartment of Psychiatry, University of Calgary, Calgary, Alberta.
Roumen V MilevDepartment of Psychiatry, Queen's University, Kingston, Ontario.
Sagar V ParikhDepartment of Psychiatry, University of Toronto, Toronto, Ontario Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
CANMAT Depression Work Group
University of Toronto · CAUniversity of British Columbia · CADalhousie University · CAQueen's University · CAUniversity of Calgary · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals.

methodsUsing the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence. Recommendations for lines of treatment were based on the quality of evidence and clinical expert consensus. "Complementary and Alternative Medicine Treatments" is the fifth of six sections of the 2016 guidelines.

resultsEvidence-informed responses were developed for 12 questions for 2 broad categories of complementary and alternative medicine (CAM) interventions: 1) physical and meditative treatments (light therapy, sleep deprivation, exercise, yoga, and acupuncture) and 2) natural health products (St. John's wort, omega-3 fatty acids; S-adenosyl-L-methionine [SAM-e], dehydroepiandrosterone, folate, Crocus sativus, and others). Recommendations were based on available data on efficacy, tolerability, and safety.

conclusionsFor MDD of mild to moderate severity, exercise, light therapy, St. John's wort, omega-3 fatty acids, SAM-e, and yoga are recommended as first- or second-line treatments. Adjunctive exercise and adjunctive St. John's wort are second-line recommendations for moderate to severe MDD. Other physical treatments and natural health products have less evidence but may be considered as third-line treatments. CAM treatments are generally well tolerated. Caveats include methodological limitations of studies and paucity of data on long-term outcomes and drug interactions.

Indexed as

Sleep DeprivationAcupuncture TherapyBiological ProductsCanadaEvidence-Based MedicineExercise TherapyHumansMajor Depressive DisorderPhototherapyPractice Guidelines as TopicBiological Productsclinical practice guidelinescomplementary and alternative medicineevidence-based medicineexerciselight therapymajor depressive disordermeta-analysisnatural health productssleep deprivationsystematic reviews

Identifiers

PMID27486153
PMCPMC4994794
OpenAlexW2493003628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.