Evidence map›Paper›PMID 27486151›Full record

SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2016

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 1. Disease Burden and Principles of Care.

Raymond W Lam, Diane McIntosh, JianLi Wang, Murray W Enns, Theo Kolivakis, Erin E Michalak, Jitender Sareen, Wei-Yi Song, Sidney H Kennedy, Glenda M MacQueen and 4 more

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 10 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 10 syntheses or guidelines pooled it, 294 citations in OpenAlex.

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81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Raymond W LamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia r.lam@ubc.ca.
Diane McIntoshDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
JianLi WangDepartment of Psychiatry, University of Calgary, Calgary, Alberta.
Murray W EnnsDepartment of Psychiatry, University of Manitoba, Winnipeg, Manitoba.
Theo KolivakisDepartment of Psychiatry, McGill University, Montréal, Quebec.
Erin E MichalakDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
Jitender SareenDepartment of Psychiatry, University of Manitoba, Winnipeg, Manitoba.
Wei-Yi SongDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
Sidney H KennedyDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Glenda M MacQueenDepartment of Psychiatry, University of Calgary, Calgary, Alberta.
Roumen V MilevDepartment of Psychiatry, Queen's University, Kingston, Ontario.
Sagar V ParikhDepartment of Psychiatry, University of Toronto, Toronto, Ontario Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Arun V RavindranDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
CANMAT Depression Work Group
University of British Columbia · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Toronto · CAMcGill University · CAQueen's University · CAUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines remains the management of major depressive disorder (MDD) in adults, with a target audience of psychiatrists and other mental health professionals.

methodsUsing the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence. Recommendations for lines of treatment were based on the quality of evidence and clinical expert consensus. This section is the first of six guidelines articles.

resultsIn Canada, the annual and lifetime prevalence of MDD was 4.7% and 11.3%, respectively. MDD represents the second leading cause of global disability, with high occupational and economic impact mainly attributable to indirect costs. DSM-5 criteria for depressive disorders remain relatively unchanged, but other clinical dimensions (sleep, cognition, physical symptoms) may have implications for depression management. e-Mental health is increasingly used to support clinical and self-management of MDD. In the 2-phase (acute and maintenance) treatment model, specific goals address symptom remission, functional recovery, improved quality of life, and prevention of recurrence.

conclusionsThe burden attributed to MDD remains high, whether from individual distress, functional and relationship impairment, reduced quality of life, or societal economic cost. Applying core principles of care, including comprehensive assessment, therapeutic alliance, support of self-management, evidence-informed treatment, and measurement-based care, will optimize clinical, quality of life, and functional outcomes in MDD.

Indexed as

Major Depressive DisorderCanadaEvidence-Based MedicineHumansPractice Guidelines as TopicSocieties, Medicalclinical assessmentclinical practice guidelinesdepressive disordersdiagnosisevidence-based medicinemajor depressive disordermeta-analysisphenomenologysystematic reviews

Identifiers

PMID27486151
PMCPMC4994789
OpenAlexW2497083932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.