Evidence map›Paper›PMID 27486150›Full record

SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2016

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 2. Psychological Treatments.

Sagar V Parikh, Lena C Quilty, Paula Ravitz, Michael Rosenbluth, Barbara Pavlova, Sophie Grigoriadis, Vytas Velyvis, Sidney H Kennedy, Raymond W Lam, Glenda M MacQueen and 4 more

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04768361 (Behavioral Activation for Major Depressive Disorder), which is not on this map. Cited by 134 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 14 pooled it
52.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04768361 nacompletednot on this mapstarted 2020, after this paper: background citation

Behavioral Activation for Major Depressive Disorder: Comparison Between Protocols With and Without Mindfulness

TypeinterventionalSponsorHospital Miguel ServetRan2020 to 2021Enrolled150ConditionsMajor Depressive DisorderArmsBehavioral Activation without Mindfulness, Behavioral Activation with Mindfulness
3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 14 syntheses or guidelines pooled it, 574 citations in OpenAlex.

  1. Psychotherapy training in psychiatry: a systematic review on the early career psychiatrists' interests and opportunities.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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  3. Guideline
  4. Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis.Photobiomodulation, photomedicine, and laser surgery · 2023
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  7. Digitalized transcranial electrical stimulation: A consensus statement.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
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  8. Guideline
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Sagar V ParikhDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan Department of Psychiatry, University of Toronto, Toronto, Ontario parikhsa@umich.edu.
Lena C QuiltyDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Paula RavitzDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Michael RosenbluthDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Barbara PavlovaDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia.
Sophie GrigoriadisDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Vytas VelyvisCBT Associates, Toronto, Ontario.
Sidney H KennedyDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Raymond W LamDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia.
Glenda M MacQueenDepartment of Psychiatry, University of Calgary, Calgary, Alberta.
Roumen V MilevDepartment of Psychiatry, Queen's University, Kingston, Ontario.
Arun V RavindranDepartment of Psychiatry, University of Toronto, Toronto, Ontario.
Rudolf UherDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia.
CANMAT Depression Work Group
University of Toronto · CADalhousie University · CAQueen's University · CAUniversity of British Columbia · CAUniversity of Calgary · CAUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Canadian Network for Mood and Anxiety Treatments (CANMAT) has revised its 2009 guidelines for the management of major depressive disorder (MDD) in adults by updating the evidence and recommendations. The target audiences for these 2016 guidelines are psychiatrists and other mental health professionals.

methodsUsing the question-answer format, we conducted a systematic literature search focusing on systematic reviews and meta-analyses. Evidence was graded using CANMAT-defined criteria for level of evidence. Recommendations for lines of treatment were based on the quality of evidence and clinical expert consensus. "Psychological Treatments" is the second of six sections of the 2016 guidelines.

resultsEvidence-informed responses were developed for 25 questions under 5 broad categories: 1) patient characteristics relevant to using psychological interventions; 2) therapist and health system characteristics associated with optimizing outcomes; 3) descriptions of major psychotherapies and their efficacy; 4) additional psychological interventions, such as peer interventions and computer- and technology-delivered interventions; and 5) combining and/or sequencing psychological and pharmacological interventions.

conclusionsFirst-line psychological treatment recommendations for acute MDD include cognitive-behavioural therapy (CBT), interpersonal therapy (IPT), and behavioural activation (BA). Second-line recommendations include computer-based and telephone-delivered psychotherapy. Where feasible, combining psychological treatment (CBT or IPT) with antidepressant treatment is recommended because combined treatment is superior to either treatment alone. First-line psychological treatments for maintenance include CBT and mindfulness-based cognitive therapy (MBCT). Patient preference, in combination with evidence-based treatments and clinician/system capacity, will yield the optimal treatment strategies for improving individual outcomes in MDD.

Indexed as

CanadaEvidence-Based MedicineHumansMajor Depressive DisorderPractice Guidelines as TopicPsychotherapySocieties, Medicalbiopsychosocialclinical practice guidelinescognitive-behavioural therapyevidence-based medicineinterpersonal therapymajor depressive disordermeta-analysismindfulness-based interventionspsychotherapysystematic reviews

Identifiers

PMID27486150
PMCPMC4994791
OpenAlexW2485472464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.